Human endometrial interleukin-6 (IL-6): in vivo messenger ribonucleic acid expression, in vitro protein production, and stimulation thereof by IL-1β

David T. Vandermolen, Yang Gu
In: Fertility and Sterility · 1996 · vol. 66(5) , pp. 741–747 · doi:10.1016/s0015-0282(16)58628-2 · PMID:8893677 · W2400693862
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This paper investigated human endometrial IL-6 mRNA expression in vivo and IL-6 protein production in vitro, finding that IL-1β stimulates its production.

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Abstract

ObjectiveTo investigate human endometrial interleukin-6 (IL-6) expression and effects thereon by IL-1 beta.DesignProspective.SettingAcademic medical center.Patient(s)Endometrial biopsy specimens from normal volunteers (n = 20) at four specific menstrual stages were used for in vivo study. Endometrial specimens for in vitro study were obtained from patients (n = 19) undergoing gynecologic surgery.Intervention(s)Time and dose-response treatment of endometria with IL-1 beta in tissue culture.Main outcome measure(s)In vivo IL-6 messenger RNA expression by Northern analysis and in vitro endometrial IL-6 protein production by assay of the conditioned media.Result(s)Midsecretory and late secretory phase endometria expressed more IL-6 messenger RNA than late proliferative phase endometria in vivo. Similarly in vitro, in pg/mg endometrium per hour secretory endometria IL-6 protein production, 25.7 +/- 7.1 (mean +/- SEM), exceeded that of proliferative endometria, 4.7 +/- 1.0. With IL-1 beta treatment, secretory endometria IL-6 protein production exceeded that of proliferative endometria. Interleukin-1 beta stimulated endometrial IL-6 protein production in time- and dose-dependent manners.Conclusion(s)Human endometrial IL-6 expression varies with the menstrual cycle, occurs more highly in secretory endometria, and in vitro is stimulated by interleukin-1 beta. Human endometrial IL-6 may therefore mediate some actions of IL-1 beta involving the endometrium and trophoblast.

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