Interleukin-1 type I receptor messenger ribonucleic acid expression in human endometrium throughout the menstrual cycle

Simón C, Carlos Simón, C Simón, G N Piquette, Piquette GN, Gary N. Piquette, A Frances, Frances A, Ana Francés, L M Westphal, Lynn M. Westphal, Westphal LM, Heinrichs WL, W L Heinrichs, Mary Lake Polan, Polan ML, M L Polan
Fertility and sterility · 1993 · vol. 59(4) , pp. 791–796 · doi:10.1016/s0015-0282(16)55861-0 · PMID:8458498 · W2411773572
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This study measured interleukin-1 type I receptor mRNA expression in human endometrium across the menstrual cycle.

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Abstract

ObjectiveTo investigate the messenger ribonucleic acid (mRNA) expression of interleukin-1 (IL-1) type I receptor in the endometrial tissue of normal patients during the menstrual cycle.DesignProspective longitudinal study.SettingDepartment of Obstetrics and Gynecology, Stanford University Medical Center, Stanford, California.PatientsTwenty fertile women between 19 and 41 years of age underwent hysterectomy for benign reasons (n = 9) and laparoscopy for tubal ligation (n = 11). In all cases, endometriosis was not visualized.InterventionsEndometrial biopsy using the Novak curette was obtained at the time of surgery.Main outcome measureTotal RNA extracted from unfractioned endometrial tissue was analyzed on Northern blots by using specific complementary deoxyribonucleic acid probes.ResultsWe found IL-1 type I receptor mRNA expression in endometrial tissue throughout the entire menstrual cycle. However, IL-1 type I receptor mRNA levels were significantly higher during both early and late luteal phases than follicular and midluteal phases.ConclusionsOur results demonstrate the presence of the IL-1 system in the human endometrium and that the receptor is regulated throughout the menstrual cycle with a 4.1-fold increased expression of the IL-1 receptor gene in the early luteal phase compared with preovulatory endometrium.

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MeSH descriptors

Endometrium Menstrual Cycle Receptors, Interleukin-1 RNA, Messenger Adult Endometrium Female Gene Expression Humans Longitudinal Studies Menstrual Cycle Prospective Studies Receptors, Interleukin-1 RNA, Messenger RNA, Messenger

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