Interleukin-1 type I receptor messenger ribonucleic acid expression in human endometrium throughout the menstrual cycle

Simón C, Carlos Simón, C Simón, G N Piquette, Piquette GN, Gary N. Piquette, A Frances, Frances A, Ana Francés, L M Westphal, Lynn M. Westphal, Westphal LM, Heinrichs WL, W L Heinrichs, Mary Lake Polan, Polan ML, M L Polan
Fertility and sterility · 1993 · vol. 59(4) , pp. 791–796 · doi:10.1016/s0015-0282(16)55861-0 · PMID:8458498 · W2411773572
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This study measured interleukin-1 type I receptor mRNA expression in human endometrium across the menstrual cycle.

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Abstract

OBJECTIVE: To investigate the messenger ribonucleic acid (mRNA) expression of interleukin-1 (IL-1) type I receptor in the endometrial tissue of normal patients during the menstrual cycle. DESIGN: Prospective longitudinal study. SETTING: Department of Obstetrics and Gynecology, Stanford University Medical Center, Stanford, California. PATIENTS: Twenty fertile women between 19 and 41 years of age underwent hysterectomy for benign reasons (n = 9) and laparoscopy for tubal ligation (n = 11). In all cases, endometriosis was not visualized. INTERVENTIONS: Endometrial biopsy using the Novak curette was obtained at the time of surgery. MAIN OUTCOME MEASURE: Total RNA extracted from unfractioned endometrial tissue was analyzed on Northern blots by using specific complementary deoxyribonucleic acid probes. RESULTS: We found IL-1 type I receptor mRNA expression in endometrial tissue throughout the entire menstrual cycle. However, IL-1 type I receptor mRNA levels were significantly higher during both early and late luteal phases than follicular and midluteal phases. CONCLUSIONS: Our results demonstrate the presence of the IL-1 system in the human endometrium and that the receptor is regulated throughout the menstrual cycle with a 4.1-fold increased expression of the IL-1 receptor gene in the early luteal phase compared with preovulatory endometrium.

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MeSH descriptors

Endometrium Menstrual Cycle Receptors, Interleukin-1 RNA, Messenger Adult Adult Endometrium Endometrium Female Female Gene Expression Gene Expression Humans Humans Longitudinal Studies Longitudinal Studies Menstrual Cycle Menstrual Cycle Prospective Studies Prospective Studies

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