Danazol suppression of luteinizing hormone secretion: a role for danazol-androgen receptor interaction within the brain-pituitary complex
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This study investigated how danazol suppresses luteinizing hormone secretion by examining the interaction between danazol and androgen receptors in the brain and pituitary gland.
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Abstract
We investigated the relationship between intracellular androgen and estrogen receptors within the brain-pituitary complex and danazol suppression of luteinizing hormone secretion in castrated rats. Danazol did not influence 3H-estradiol-estrogen receptor interactions within the brain and pituitary but did suppress 3H-dihydrotestosterone-androgen receptor interactions within this neuroendocrine complex. To study the significance of these danazol-androgen receptor interactions, the drug was administered to androgen receptor-deficient pseudohermaphrodite or flutamide-treated male rats. In both instances, danazol suppression of luteinizing hormone release was markedly attenuated or absent. These findings point to danazol-androgen receptor interactions within the brain-pituitary complex as a key step in this drug's antigonadotropic actions. Whether the active drug form is danazol itself or a metabolite is subject to further study.
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Cited by (13)
- Evaluation of Positive Inotropic Activity Induced bya Danazol Derivative in Isolated Rat Heart Model 2013
- Danazol: Prolonged suppression of gonadotropins after subcutaneous administration in the castrate male rat 1994
- Progesterone receptor induction by danazol in cultured cancer cells and the rat uterus 1992
- Thermoregulatory and endocrine effects of a low dose of danazol in postmenopausal women: Interaction with the effect of naloxone 1991
- The Inhibitory Effect of Synthetic Steroids on Proestrous Gonadotropin Release in theRat 1989
- Studies on the mechanism of action of danazol and gestrinone (R2323) in the rat: evidence for a masked estrogen component* 1989
- Changes in the biochemical composition of semen following danazol plus testosterone enanthate administration to the langur monkey 1985
- Changes in the shbg concentration during danazol treatment 1984
- Danazol treatment of severely symptomatic fibrocystic breast disease and long‐term follow‐up—the Hjørring project 1984
- Regression of endometriosis following shorter treatment with, or lower dose of danazol: Comparison of pre‐ and post‐treatment laparoscopic findings in the Scandinavian multi‐center study 1984
- The effect of danazol on gonadotropin secretion during the follicular phase of the menstrual cycle 1983
- Influence of danazol treatment during the luteal phase on pituitary and ovarian function during the subsequent menstrual cycle 1982
- Dynamic tests of hypothalamic and pituitary function in women treated with danazol 1982
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