Increased Accumulation of Estrogen Receptors in Pituitary Nuclei of Danazol Treated Rats

John E. Creange, G. O. Potts, H. Philip Schane
In: Biology of Reproduction · 1979 · vol. 21(1) , pp. 27–32 · doi:10.1095/biolreprod21.1.27 · PMID:486643 · W2100928213
article OA: closed CC0 ⤵ 11 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Danazol treatment in ovariectomized rats increased estradiol receptor amounts in pituitary nuclei and decreased pituitary and hypothalamic estradiol concentrations relative to plasma.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Orally administered danazol decreased the concentration of parenterally administered [3H]-estradiol in pituitary and hypothalamus, but not in cerebral cortex, relative to plasma levels of labeled hormone in adult, ovariectomized rats. Similarly, danazol increased the amounts of estradiol receptors in pituitary nuclei of these animals. These findings are consistent with the concept that danazol acts at the level of the pituitary and (probably) the hypothalamus in rats to inhibit the production and/or release of gonadotropins.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (18)

Cited by (11)

Source provenance

openalex
last seen: 2026-05-11T04:57:32.809404+00:00
License: CC0 · commercial use OK