G. O. Potts

Orally administered danazol decreased the concentration of parenterally administered [3H]-estradiol in pituitary and hypothalamus, but not in cerebral cortex, relative to plasma levels of labeled hormone in adult, ovariectomized rats. Simil…

Danazol was previously reported to be an oral contraceptive in the rhesus monkey at doses of 200 and 400 mg/monkey/day for 90 days. The drug is now shown to be an effective long-term inhibitor of ovarian function in the monkey. In the final…

Abstract Die aus Danazol (I) gebildeten Metaboliten werden identifiziert.

Metabolites of danazol (17 alpha-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol), an orally effective pituitary gonadotropin inhibitory agent devoid of estrogenic and progestational activites, were isolated from urine of a female subject who h…