Pharmacology and Pharmacokinetics of Danazol
This paper reviews the pharmacology and pharmacokinetics of danazol, referencing its antiglyconeogenic activity, effects on gonadotropins, steroid blood levels, steroidogenesis, and receptor binding in various species.
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This article reviews the pharmacology and pharmacokinetics of danazol, drawing on preclinical and clinical studies in animals (e.g., rats and rhesus monkeys) and human volunteers, including work on its absorption, distribution, metabolism, receptor binding, and effects on endocrine function such as gonadotropins and steroidogenesis. Across these studies, danazol is characterized as a synthetic steroid derivative with activity consistent with inhibition of steroidogenesis and suppression of pituitary gonadotropins, with measured plasma pharmacokinetics supported by radioimmunoassays. A major caveat is that the paper is a compilation of findings from diverse referenced studies rather than a single new experiment with a unified experimental design or dosing regimen. Relevance to endometriosis: it explicitly includes an antedated symposium proceedings reference on danazol in “Recent Advances in Endometriosis,” and danazol is a historical endometriosis therapy context in the cited pharmacology summaries, though the article’s main focus is the drug’s pharmacology and pharmacokinetics.
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References (26)
- A competitive radioligand assay for danazol (17α-pregn-4-en-20-yno[2,3-d]isoxazol-17-ol) using pregnant guinea pig plasma via openalex
- A radioimmumoassay for danazol (17α-Pregna-2,4-Dien-20-Yno[2,3-d]Isoxazol-17-OL) via openalex
- Clinical Studies with an Antigonadotropin-Danazol via openalex
- Danazol—a Synthetic Steroid Derivative with Interesting Physiologic Properties via openalex
- Danazol Binding to Rat Androgen, Glucocorticoid, Progesterone, and Estrogen Receptors: Correlation With Biologic Activity via openalex
- Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats via openalex
- Danazol Inhibits Steroidogenesis via openalex
- Danazol Inhibits Steroidogenesis in the Rat Testis<i>in Vitro</i> via openalex
- Effects of danazol on gonadotropin levels in castrated rhesus monkeys. via openalex
- Hormonal changes associated with Danazol therapy. via openalex
- Oral Contraceptive Activity of Danazol in the Rhesus Monkey via openalex
- Pharmacology of danazol. via openalex
- Pituitary and Testicular Function Studies. I. Experience with a New Gonadal Inhibitor, 17α-Pregn-4-en-20-yno-(2,3-d) isoxazol-17-ol (Danazol)<sup>1</sup> via openalex
- Pituitary Gonadotropin Inhibitory Activity of Danazol via openalex
- Progestational activity of Danazol in the human female subject via openalex
- Radioimmunoassay for Danazol in Human and Monkey Plasma via openalex
- The absorption, distribution and metabolic fate of danazol in rats, monkeys and human volunteers. via openalex
- The Effect of Danazol on Anterior Pituitary Function via openalex
- The effects of danazol on gonadotropins and steroid blood levels in normal and anovulatory women. via openalex
- doi:10.1016/0014-5793(77)80577-2 via openalex
- doi:10.1098/rspb.1937.0004 via openalex
- doi:10.1021/jm00265a019 via openalex
- doi:10.1016/s0015-0282(16)39613-3 via openalex
- doi:10.1021/jm00337a001 via openalex
- doi:10.1016/s0022-3565(25)07926-1 via openalex
- doi:10.1095/biolreprod10.4.438 via openalex
Cited by (12)
- [<sup>3</sup>H]Dexamethasone Binding Activity in Liver Microsomes is Modulated Differently by 17 α‐Alkylated Androgens and Testosterone<i>in vivo</i> 1995
- Single oral dose pharmacokinetics and comparative bioavailability of danazol in humans 1991
- 5 Heterosteroids and Drug Research 1991
- A liquid chromatographic method for the determination of danazol in human serum 1990
- Histological Studies on the Therapeutic Effect of Sustained-Release Microspheres of a Potent LHRH Agonist (Leuprorelin Acetate) in an Experimental Endometriosis Model in Rats. 1990
- Determination of Danazol in Plasma by High Performance Liquid Chromatography 1989
- Danazol concentrations in human ovarian follicular fluid and their relationship to simultaneous serum concentrations 1988
- Analysis of danazol in serum using high-performance liquid chromatography 1987
- Sensitive and selective assay of danazol in plasma by high-performance liquid chromatography 1987
- Inhibition of steroid sulfatase activity by danazol 1984
- Medical treatment of endometriosis in infertile patients 1983
- Pharmacology and clinical effects of danazol 1982
Source provenance
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