Radioimmunoassay for Danazol in Human and Monkey Plasma

J.E. Peterson, Mary E. King, W. F. Banks, James F. Baker, Anne Jensen, R. Ross, S. Clemans, Jerome Edelson
In: Journal of Pharmaceutical Sciences · 1978 · vol. 67(10) , pp. 1425–1428 · doi:10.1002/jps.2600671026 · PMID:100593 · W2091949116
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A radioimmunoassay was developed to measure danazol levels in human and monkey plasma, allowing for pharmacokinetic and metabolic studies of the drug.

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Abstract

A sensitive method is described for the radioimmunoassay of danazol in monkey and human plasma. Antiserum was developed in rabbits, and a second antibody was used to separate bound from free danazol. The radioimmunoassay was specific for danazol, and the limit of detection ranged from 1.4 to 2.8 ng/ml. Exogeneous danazol could be quantitated accurately in both monkey and human plasma. The radioimmunoassay results agreed with values obtained by inverse isotope dilution after intravenous administration of 14C-danazol to monkeys. The assay was used successfully to measure danazol in plasma from human volunteers receiving 200 mg of danazol.

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