A liquid chromatographic method for the determination of danazol in human serum

Krzysztof Selinger, Howard Hill, June A. Anslow, Diana Gash
In: Journal of Pharmaceutical and Biomedical Analysis · 1990 · vol. 8(1) , pp. 79–84 · doi:10.1016/0731-7085(90)80010-m · PMID:2131807 · W2026397193
article OA: closed CC0 ⤵ 9 in-corpus citations
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This paper describes a liquid chromatography method developed for accurately quantifying danazol levels within human serum samples.

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Abstract

A liquid chromatographic method for the determination of danazol in human serum has been developed. Reversed-phase C8 and C18 columns were used with a column-switching valve, isocratic elution and UV detection. Sample pretreatment involved extraction of the drug with pentane-methylene chloride. The method enabled the measurement of the drug at a concentration as low as 1 ng ml-1, with precision of 15.0% and accuracy of 8.3%. The method was used to run a two way replicated pharmacokinetic study of danazol. The main pharmacokinetic parameters were (mean of two periods): AUCinf = 480.94 ng x h ml-1, Cmax = 53.2 ng ml-1, tmax = 2.5 h, t0.5 = 18.00 h.

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