A liquid chromatographic method for the determination of danazol in human serum
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This paper describes a liquid chromatography method developed for accurately quantifying danazol levels within human serum samples.
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Abstract
A liquid chromatographic method for the determination of danazol in human serum has been developed. Reversed-phase C8 and C18 columns were used with a column-switching valve, isocratic elution and UV detection. Sample pretreatment involved extraction of the drug with pentane-methylene chloride. The method enabled the measurement of the drug at a concentration as low as 1 ng ml-1, with precision of 15.0% and accuracy of 8.3%. The method was used to run a two way replicated pharmacokinetic study of danazol. The main pharmacokinetic parameters were (mean of two periods): AUCinf = 480.94 ng x h ml-1, Cmax = 53.2 ng ml-1, tmax = 2.5 h, t0.5 = 18.00 h.
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References (7)
- Analysis of danazol in serum using high-performance liquid chromatography via openalex
- A radioimmumoassay for danazol (17α-Pregna-2,4-Dien-20-Yno[2,3-d]Isoxazol-17-OL) via openalex
- Isolation, synthesis, and biological activity of five metabolites of danazol via openalex
- Pharmacology and pharmacokinetics of danazol via openalex
- Radioimmunoassay for danazol in human and monkey plasma via openalex
- Sensitive and selective assay of danazol in plasma by high-performance liquid chromatography via openalex
- doi:10.1177/030006057700500103 via openalex
Cited by (8)
- Danazol 2022
- Exploring the Impact of Intestinal Fluid Components on the Solubility and Supersaturation of Danazol 2021
- Enhanced bioavailability of danazol nanosuspensions by wet milling and high-pressure homogenization 2016
- Formulation of a danazol cocrystal with controlled supersaturation plays an essential role in improving bioavailability 2013
- Square-wave adsorptive stripping voltammetric determination of danazol in capsules 2006
- Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug 2005
- Voltammetric study of danazol and its determination in capsules and spiked biological fluids 2004
- Conventional and micellar liquid chromatography method development for danazol and validation in capsules 2003
Source provenance
- openalex
- last seen: 2026-05-11T06:10:27.824888+00:00
- pubmed
- last seen: 2026-10-08T21:08:38.374512+00:00
- unpaywall
- last seen: 2026-10-10T06:25:47.132674+00:00
License: CC0
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