Increased accumulation of estrogen receptors in pituitary nuclei of danazol treated rats
Lab / animal
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⤵ 11 in-corpus citations
AI-generated summary
Danazol treatment in ovariectomized rats increased estradiol receptor amounts in pituitary nuclei and decreased pituitary and hypothalamic estradiol concentrations relative to plasma.
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Abstract
Orally administered danazol decreased the concentration of parenterally administered [3H]-estradiol in pituitary and hypothalamus, but not in cerebral cortex, relative to plasma levels of labeled hormone in adult, ovariectomized rats. Similarly, danazol increased the amounts of estradiol receptors in pituitary nuclei of these animals. These findings are consistent with the concept that danazol acts at the level of the pituitary and (probably) the hypothalamus in rats to inhibit the production and/or release of gonadotropins.
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References (18)
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Cited by (11)
- Danazol 2022
- Progesterone receptor induction by danazol in cultured cancer cells and the rat uterus 1992
- Studies on the mechanism of action of danazol and gestrinone (R2323) in the rat: evidence for a masked estrogen component 1989
- Cytoplasmic and nuclear estrogen binding capacity in the rat uterus during treatment with danazol and testosterone 1986
- Danazol and migraine 1984
- Regression of endometriosis following shorter treatment with, or lower dose of danazol. Comparison of pre- and post-treatment laparoscopic findings in the Scandinavian multi-center study 1984
- Danazol 1982
- Influence of danazol treatment during the luteal phase on pituitary and ovarian function during the subsequent menstrual cycle 1982
- Danazol suppression of luteinizing hormone secretion: a role for danazol-androgen receptor interaction within the brain-pituitary complex 1981
- Androgen uptake in the female reproductive system of a nonhuman primate 1981
- In vitro effect of danazol on luteinizing hormone-releasing hormone-stimulated luteinizing hormone release in rat anterior pituitary cell cultures in vitro 1981
Source provenance
- openalex
- last seen: 2026-05-11T04:57:32.809404+00:00
- pubmed
- last seen: 2026-10-08T21:57:33.264577+00:00
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