Danazol suppression of luteinizing hormone secretion: a role for danazol-androgen receptor interaction within the brain-pituitary complex
Lab / animal
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⤵ 13 in-corpus citations
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This study investigated how danazol suppresses luteinizing hormone secretion by examining the interaction between danazol and androgen receptors in the brain and pituitary gland.
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Abstract
We investigated the relationship between intracellular androgen and estrogen receptors within the brain-pituitary complex and danazol suppression of luteinizing hormone secretion in castrated rats. Danazol did not influence 3H-estradiol-estrogen receptor interactions within the brain and pituitary but did suppress 3H-dihydrotestosterone-androgen receptor interactions within this neuroendocrine complex. To study the significance of these danazol-androgen receptor interactions, the drug was administered to androgen receptor-deficient pseudohermaphrodite or flutamide-treated male rats. In both instances, danazol suppression of luteinizing hormone release was markedly attenuated or absent. These findings point to danazol-androgen receptor interactions within the brain-pituitary complex as a key step in this drug's antigonadotropic actions. Whether the active drug form is danazol itself or a metabolite is subject to further study.
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Cited by (12)
- Danazol: prolonged suppression of gonadotropins after subcutaneous administration in the castrate male rat 1994
- Progesterone receptor induction by danazol in cultured cancer cells and the rat uterus 1992
- Thermoregulatory and endocrine effects of a low dose of danazol in postmenopausal women: interaction with the effect of naloxone 1991
- Studies on the mechanism of action of danazol and gestrinone (R2323) in the rat: evidence for a masked estrogen component 1989
- The inhibitory effect of synthetic steroids on proestrous gonadotropin release in the rat 1989
- Changes in the biochemical composition of semen following danazol plus testosterone enanthate administration to the langur monkey 1985
- Changes in the SHBG concentration during danazol treatment 1984
- Danazol treatment of severely symptomatic fibrocystic breast disease and long-term follow-up--the Hjørring project 1984
- Regression of endometriosis following shorter treatment with, or lower dose of danazol. Comparison of pre- and post-treatment laparoscopic findings in the Scandinavian multi-center study 1984
- The effect of danazol on gonadotropin secretion during the follicular phase of the menstrual cycle 1983
- Influence of danazol treatment during the luteal phase on pituitary and ovarian function during the subsequent menstrual cycle 1982
- Dynamic tests of hypothalamic and pituitary function in women treated with danazol 1982
Source provenance
- openalex
- last seen: 2026-05-14T06:19:26.718892+00:00
- pubmed
- last seen: 2026-10-08T21:58:37.372514+00:00
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