Danazol therapy in hormone-sensitive mammary carcinoma

Thomas G. Peters, J Lewis, Edward J. Wilkinson, Thomas M. Fuhrman
In: Cancer · 1977 · vol. 40(6) , pp. 2797–2800 · doi:10.1002/1097-0142(197712)40:6<2797::aid-cncr2820400607>3.0.co;2-9 · PMID:412578 · W2044496053
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Danazol therapy induced mammary carcinoma regression in rats and significantly inhibited carcinogenesis when administered after DMBA exposure.

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Abstract

The effect of Danazol, a synthetic gonadotropin inhibitor, on two groups of Sprague-Dawley rats with dimethylbenze (a) anthracine (DMBA) induced mammary carcinoma was studied. Twenty-four (83%) of 29 control animals developed mammary tumors. Forty-four rats in one treatment group received Danazol after tumor reached 0.5 cm in diameter. Twenty-nine (66%) demonstrated tumor regression (p less than 0.005) and in 16 (36%) tumor disappeared (p less than 0.005). In a second treatment group (given Danazol daily after administration of DMBA), only seven of 50 rats (14%) developed palpable mammary carcinoma (p less than 0.0005). Danazol therapy resulted in regression of established mammary carcinoma in rats, and produced a striking inhibition of carcinogenesis in those animals treated from the time DMBA was administered. Danazol is clinically safe; studies using it in the treatment of breast cancer in women who are candidates for hormonal ablative therapy seem warranted.

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