Danazol induced hypercalcemia in breast cancer

Silvana Martino
In: Breast Cancer Research and Treatment · 1984 · vol. 4(1) , pp. 53–54 · doi:10.1007/bf01806989 · PMID:6697011 · W2026669492
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This paper describes cases of hypercalcemia in breast cancer patients treated with danazol and discusses potential mechanisms for this adverse effect.

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This paper reports observations of hypercalcemia that occurred after danazol treatment in the context of breast cancer. The account is based on clinical experience rather than a controlled comparative design, and the limited details provided in the article constrain conclusions about mechanisms or frequency. Danazol has also been analyzed previously in endometriosis, including a follow-up of 100 cases, but this short breast-cancer report focuses on hypercalcemia induced during breast cancer therapy without extending to endometriosis outcomes. Relevance to endometriosis: danazol is cited as having been used in endometriosis treatment in referenced work, though the paper’s main focus is danazol-induced hypercalcemia in breast cancer.

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References Coombes RC, Dearnaley D, Humphreys J, Gazet JC, Ford HT, Nash AG, Mashiter K, Powles TJ: Danazol treatment of advanced breast cancer. Cancer Treat Rep 64: 1073–1076, 1980 Peters TG, Lewis JD, Wilkinson ED, Furhman TM: Danazol therapy in hormone-sensitive mammary carcinoma. Cancer 40: 2797–2800, 1977 Barbieri RL, Evans ST, Kistner RW: Danazol in the treatment of endometriosis: analysis of 100 cases with a 4-year follow-up. Fertil Steril 37: 737, 1982 Author information Authors and Affiliations Rights and permissions About this article Cite this article Martino, S. Danazol induced hypercalcemia in breast cancer. Breast Cancer Res Tr 4, 53–54 (1984). https://doi.org/10.1007/BF01806989 Issue date: DOI: https://doi.org/10.1007/BF01806989

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