Mechanism of induction of luteal phase defects by danazol

Ricardo H. Asch, E. Fernández, Theresa M. Siler-Khodr, Andrzej Bartke, Carl J. Pauerstein
In: American Journal of Obstetrics and Gynecology · 1980 · vol. 136(7) , pp. 932–937 · doi:10.1016/0002-9378(80)91054-6 · PMID:6767405 · W2246679525
article OA: closed CC0 ⤵ 16 in-corpus citations
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Danazol treatment was found to induce luteal phase defects by suppressing ovulation and affecting corpus luteum function.

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Abstract

The effects of danazol on the luteal phase of cycling rhesus monkeys and on the ability of the intact rhesus monkey to respond to hCG stimulation were studied in two experiments. In a third experiment the impact of danazol upon the response of the decapsulated mouse testis to hCG stimulation was evaluated. These experiments demonstrated that danazol shortens the luteal phase and decreases progesterone production in intact monkeys via a direct effect on the gonad.

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