Elimination of ovulation and menstrual cyclicity (with danazol) improves dysphoric premenstrual syndromes.
article
OA: closed
CC0
⤵ 4 in-corpus citations
AI-generated summary
Danazol treatment in women with dysphoric PMS resulted in symptom-free periods during anovulatory cycles, indicating the drug's benefit stems from ovulation suppression.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
OBJECTIVE: To assess whether the therapeutic effect of danazol on premenstrual syndromes (PMS) is associated with suppression of ovulation. DESIGN: After 1 month on placebo, we administered 200 mg/d of danazol for 90 days to 24 women with dysphoric PMS. Symptoms during ovulatory cycles were compared with anovulatory periods. SETTING: Outpatient PMS program in a general hospital. PATIENTS: Twenty-four women who had dysphoric PMS and otherwise were physically and mentally healthy. INTERVENTIONS: None (except the oral medication). MAIN OUTCOME MEASURE: Prospective daily monitoring of symptoms with the Daily Rating Form, before, during, and after treatment. RESULTS: Twenty of 23 anovulatory periods were symptom-free versus 6 of 32 ovulatory periods (chi 2 = 15.63, P = 0.0002). CONCLUSION: The beneficial effect of danazol as treatment depends mostly on achieving an an-ovulatory state and elimination of hormonal cyclicity and not on the drug per se.
My notes (saved in your browser only)
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (25)
- A clinical trial using danazol for the treatment of premenstrual tension via openalex
- Danazol and the premenstrual syndrome. via openalex
- Danazol Binding to Rat Androgen, Glucocorticoid, Progesterone, and Estrogen Receptors: Correlation With Biologic Activity via openalex
- Danol for Premenstrual Syndrome: A Preliminary Report of a Placebo-Controlled Double-Blind Study via openalex
- Dosage aspects of danazol therapy in endometriosis: Short-term and long-term effectiveness via openalex
- Endocrine effects of danazol in menstruating women. via openalex
- Lasting response to ovariectomy in severe intractable premenstrual syndrome via openalex
- Role of danazol in relieving the premenstrual syndrome. via openalex
- The Effect of Danazol on Anterior Pituitary Function via openalex
- The effects of danazol on gonadotropins and steroid blood levels in normal and anovulatory women. via openalex
- The influence of danazol on pituitary function and on the ovarian follicular hormone secretion in premenopausal women via openalex
- The use of danazol in the management of endometriosis. via openalex
- W1618997004 via openalex
- W3158160561 via openalex
- W1970836431 via openalex
- W1989998247 via openalex
- W1996115136 via openalex
- W2000904191 via openalex
- W2008914421 via openalex
- W2076133968 via openalex
- W2128682432 via openalex
- W2140896143 via openalex
- W2145860585 via openalex
- W2422487717 via openalex
- W2464396040 via openalex
Cited by (4)
- Premenstrual syndrome 2008
- Randomized controlled trial of the management of premenstrual syndrome and premenstrual mastalgia using luteal phase–only danazol 1999
- A randomized, placebo-controlled, crossover trial of danazol for the treatment of premenstrual syndrome 1995
- Danazol: Prolonged suppression of gonadotropins after subcutaneous administration in the castrate male rat 1994
Source provenance
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0
· commercial use OK