Elimination of ovulation and menstrual cyclicity (with danazol) improves dysphoric premenstrual syndromes
Non-randomised trial
OA: closed
CC0
⤵ 4 in-corpus citations
AI-generated summary
Danazol treatment in women with dysphoric PMS resulted in symptom-free periods during anovulatory cycles, indicating the drug's benefit stems from ovulation suppression.
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Abstract
OBJECTIVE: To assess whether the therapeutic effect of danazol on premenstrual syndromes (PMS) is associated with suppression of ovulation.
DESIGN: After 1 month on placebo, we administered 200 mg/d of danazol for 90 days to 24 women with dysphoric PMS. Symptoms during ovulatory cycles were compared with anovulatory periods.
SETTING: Outpatient PMS program in a general hospital.
PATIENTS: Twenty-four women who had dysphoric PMS and otherwise were physically and mentally healthy.
INTERVENTIONS: None (except the oral medication).
MAIN OUTCOME MEASURE: Prospective daily monitoring of symptoms with the Daily Rating Form, before, during, and after treatment.
RESULTS: Twenty of 23 anovulatory periods were symptom-free versus 6 of 32 ovulatory periods (chi 2 = 15.63, P = 0.0002).
CONCLUSION: The beneficial effect of danazol as treatment depends mostly on achieving an an-ovulatory state and elimination of hormonal cyclicity and not on the drug per se.
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Cited by (4)
- Premenstrual syndrome 2008
- Randomized controlled trial of the management of premenstrual syndrome and premenstrual mastalgia using luteal phase-only danazol 1999
- A randomized, placebo-controlled, crossover trial of danazol for the treatment of premenstrual syndrome 1995
- Danazol: prolonged suppression of gonadotropins after subcutaneous administration in the castrate male rat 1994
Source provenance
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-10-08T21:04:17.981133+00:00
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