Danol for Premenstrual Syndrome: A Preliminary Report of a Placebo-Controlled Double-Blind Study
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This double-blind, placebo-controlled study investigated the efficacy of danazol, a synthetic steroid, for treating premenstrual syndrome by suppressing hormonal fluctuations.
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Abstract
Introduction Danol (danazoI) is a synthetic steroid which has been found to be effective in the treatment of a variety of gynaecological and endocrinological disorders including endometriosis (Young & Blackmore 1977), fibroadenosis (Mansel 1982) and other benign diseases of the breast, and menorrhagia (Chimbira 1980). Danol can suppress the hormonal fluctuations of the menstrual cycle and might, therefore, be expected to be helpful to patients with the premenstrual syndrome (PMS). Indeed, it appears that many gynaecologists use Danol successfully in PMS although its efficacy has not, until now, been put to the test in doubleblind, placebo-controlled trials.
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References (3)
- REDUCTION OF MENSTRUAL BLOOD LOSS BY DANAZOL IN UNEXPLAINED MENORRHAGIA: LACK OF EFFECT OF PLACEBO via openalex
- The use of danazol in the management of endometriosis. via openalex
- W3143158152 via openalex
Cited by (5)
- Gynecologic Disorders 1992
- Elimination of ovulation and menstrual cyclicity (with danazol) improves dysphoric premenstrual syndromes 1991
- Elimination of ovulation and menstrual cyclicity (with danazol) improves dysphoric premenstrual syndromes. 1991
- The treatment of late luteal phase dysphoric disorder 1991
- Cyclical mastopathy: A critical review of therapy 1988
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