The treatment of late luteal phase dysphoric disorder

S Steinberg, Susanne Steinberg
Life sciences · 1991 · vol. 49(11) , pp. 767–802 · doi:10.1016/0024-3205(91)90244-6 · PMID:1875788 · W2065754499
Review OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-14 ⓘ

This paper reviews the treatment of late luteal phase dysphoric disorder, commonly known as premenstrual dysphoric disorder (PMDD).

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

This mini-review provides a comprehensive discussion of the management of the late luteal phase dysphoric disorder (LLPDD). The various treatments will be described with particular attention to their efficacy and the nature of side effects. These include: psychoactive drugs (lithium, anxiolytics, antidepressants), nutritional agents (L-tryptophan, Vitamin B6, prostaglandins precursors and inhibitors), dopamine agonists, diuretics, antihypertensives, hormonal interventions (gonadotrophin releasing hormone analogues, oestradiol, tamoxifen, progesterone, danazol, and oral contraceptives). Less attention has been given to non-pharmacologic approaches such as diet, exercise and psychotherapy. The availability of an operational definition of LLPDD in the DSM-III-R and the improvement in research methodology has provided a clearer direction for clinical management and for future investigations.

My notes (saved in your browser only)

MeSH descriptors

Premenstrual Syndrome Exercise Female Hormones Hormones Humans Luteal Phase Premenstrual Syndrome Premenstrual Syndrome Psychotherapy

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:05:43.569505+00:00
unpaywall
last seen: 2026-10-11T06:28:45.473802+00:00
License: CC0 · commercial use OK