Elimination of ovulation and menstrual cyclicity (with danazol) improves dysphoric premenstrual syndromes

Uriel Halbreich, Nathan Rojansky, Steven F. Palter
In: Fertility and Sterility · 1991 · vol. 56(6) , pp. 1066–1069 · doi:10.1016/s0015-0282(16)54718-9 · W4296816583
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Danazol treatment suppressed ovulation and menstruation, leading to the elimination of symptoms in women with severe premenstrual syndrome.

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Abstract

ObjectiveTo assess whether the therapeutic effect of danazol on premenstrual syndromes (PMS) is associated with suppression of ovulation.DesignAfter 1 month on placebo, we administered 200 mg/d of danazol for 90 days to 24 women with dysphoric PMS. Symptoms during ovulatory cycles were compared with anovulatory periods.SettingOutpatient PMS program in a general hospital.PatientsTwenty-four women who had dysphoric PMS and otherwise were physically and mentally healthy.InterventionsNone (except the oral medication).Main outcome measureProspective daily monitoring of symptoms with the Daily Rating Form, before, during, and after treatment.ResultsTwenty of 23 anovulatory periods were symptom-free versus 6 of 32 ovulatory periods (chi 2 = 15.63, P = 0.0002).ConclusionThe beneficial effect of danazol as treatment depends mostly on achieving an an-ovulatory state and elimination of hormonal cyclicity and not on the drug per se.

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