Robert Hawthorn

Summary This double-blind, randomized, crossover study compared the efficacy and safety of danazol (100 mg twice daily) with matching placebo in the treatment of severe premenstrual syndrome. Nineteen patients were randomly allocated to rec…

SummaryA double blind placebo controlled cross over study was conducted to assess the response of women with severe premenstrual syndrome to treatment with danazol. Daily self assessment of clinical state was measured using the Moos menstru…

Introduction Danol (danazoI) is a synthetic steroid which has been found to be effective in the treatment of a variety of gynaecological and endocrinological disorders including endometriosis (Young & Blackmore 1977), fibroadenosis (Mansel …