Treatment with a luteinising hormone-releasing hormone analogue (Buserelin) in danazol-resistant endometriosis patients

Franssen AM, Anton M.H.W. Franssen, A M Franssen, R. Rolland, Rolland R, Dev R. Chadha, Chadha DR, D R Chadha, W N Willemsen, Willemsen WN, Wim N.P. Willemsen, Vemer HM, H M Vemer
European journal of obstetrics, gynecology, and reproductive biology · 1986 · vol. 23(5-6) , pp. 379–386 · doi:10.1016/0028-2243(86)90173-5 · PMID:3100357 · W2040632335
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Buserelin treatment was evaluated in patients with endometriosis who did not respond to danazol therapy.

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Abstract

Luteinising hormone-releasing hormone agonist (Buserelin) therapy administered for a period of 6 months in 4 patients with longstanding, severe, danazol-resistant endometriosis, was found to be effective in reducing all complaints related to endometriosis. From 2 weeks on, nearly half of the E2 determinations were below the sensitivity level of the assay, while the other values were predominantly in the range of the early follicular phase. Side effects associated with the induced hypoestrogenemia were mild and well tolerated. After six months of follow-up without treatment, one patient who desired pregnancy conceived shortly after cessation of therapy and one patient showed lasting amelioration of her complaints. The symptoms relapsed in the other two, possibly due to inadequate dose and/or duration of treatment.

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Condition tags

endometriosis

MeSH descriptors

Buserelin Danazol Endometriosis Pregnadienes Adult Buserelin Buserelin Danazol Drug Resistance Endometriosis Endometriosis Estradiol Estradiol Female Follicle Stimulating Hormone Follicle Stimulating Hormone Humans Luteinizing Hormone Luteinizing Hormone Lynestrenol

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (3)

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