Selective inhibition by danazol of follicle stimulating hormone during the luteal phase

Brian A. Lieberman, B A Lieberman, Sophie Pluta Thom, S Thom, M. A. F. Murray, M A Murray, H. S. Jacobs
British journal of obstetrics and gynaecology · 1977 · vol. 84(1) , pp. 55–57 · doi:10.1111/j.1471-0528.1977.tb12468.x · PMID:321001 · W2025738652
Non-randomised trial OA: closed CC0 ⤵ 13 in-corpus citations
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Daily danazol administration during the luteal phase selectively impaired the follicle-stimulating hormone response to LHRH in normally menstruating women without affecting other hormonal levels.

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Abstract

In each of six healthy, normally menstruating women, serum oestradiol, progesterone, basal and post luteinizing hormone releasing hormone (LHRH) gonadotrophin measurements were made during the luteal phase of a normal cycle and in a subsequent cycle in which 800 mg of danazol was given daily from the fifth day after the presumptive date of ovulation. No differences in the serum oestradiol, progesterone, or basal gonadotrophin levels were detected, but there was a selective impairment of the follicle stimulating hormone response to LHRH. The implications of these findings are discussed.

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MeSH descriptors

Danazol Follicle Stimulating Hormone Luteal Phase Menstruation Pregnadienes Danazol Estradiol Estradiol Female Follicle Stimulating Hormone Follicle Stimulating Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Luteal Phase Luteinizing Hormone Luteinizing Hormone Menstruation Pregnadienes Progesterone

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