Nafarelin versus danazol in the treatment of endometriosis
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This study compared the efficacy and side effects of nafarelin and danazol for treating endometriosis.
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Abstract
A double-blind, double-dummy, 6-month multicenter study comparing the effects of nafarelin and danazol in the treatment of endometriosis was completed recently by investigators from 13 institutions in seven European countries. The 194 patients (aged 18 to 45 years) selected for the study were divided into two groups. One group received nafarelin, 200 micrograms twice daily, and placebo capsules identical to danazol, twice daily. The other group received danazol capsules, 200 mg twice daily, and a placebo nasal spray identical to nafarelin, twice daily. A comparison of decreases in both groups of American Fertility Society endometriosis scores and in severity scores developed by the investigators indicates that nafarelin and danazol are equally effective in the treatment of endometriosis.
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References (6)
- Administration of Nasal Nafarelin as Compared with Oral Danazol for Endometriosis via openalex
- Clinical Studies with an Antigonadotropin-Danazol via openalex
- Endometriosis: treatment with gonadotropin-releasing hormone agonist Buserelin via openalex
- The treatment of endometriosis with Danazol. via openalex
- W2014486464 via openalex
- W2410955081 via openalex
Cited by (33)
- A systematic literature review on patient-reported outcome domains and measures in nonsurgical efficacy trials related to chronic pain associated with endometriosis: an urgent call to action 2024
- Gonadotropin-releasing hormone analogues for endometriosis 2023
- Endometriosis 2021
- Medical therapy options for endometriosis related pain, which is better? A systematic review and network meta-analysis of randomized controlled trials 2020
- Reevaluating response and failure of medical treatment of endometriosis: a systematic review 2017
- Analogs of Luteinizing Hormone-Releasing Hormone in the Treatment of Endometriosis 2015
- Endometriosis 2012
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 2010
- Medikamentöse Schmerztherapie der Endometriose 2008
- Endometriosis 2008
- Ovulation suppression for endometriosis for women with subfertility 2007
- Endometriosis 2007
- GnRH analogs: Options for endometriosis-associated pain treatment 2006
- Management of the Pain Associated with Endometriosis: An Update of the Painful Problems 2006
- GnRH agonist and antagonist: Options for endometriosis pain treatment 2006
- Optimizing Gonadotropin-Releasing Hormone Agonist Therapy in Women with Endometriosis 2004
- Ovulation suppression for endometriosis 2003
- Tratamiento de la endometriosis y medicina basada en la evidencia 2003
- The Treatment of Endometriosis 2002
- Consensus statement for the management of chronic pelvic pain and endometriosis: proceedings of an expert-panel consensus process 2002
- Treatment of Endometriosis 2001
- Medical and Surgical Therapies for Pain Associated with Endometriosis 2001
- Endometriosis 2000
- Medical management of endometriosis and infertility 2000
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
- The evidence for the management of endometriosis 1998
- A randomized, comparative trial of triptorelin depot (D-Trp6-LHRH) and danazol in the treatment of endometriosis 1995
- Gonadotropin-releasing hormone agonists 1994
- Changing concepts of medical treatment of endometriosis 1993
- Endometriosis in the adolescent and teenage female 1993
- Goserelin 1991
- Nafarelin 1990
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- europepmc
- last seen: 2026-07-26T06:08:39.051465+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:12:10.587122+00:00
- unpaywall
- last seen: 2026-06-02T02:00:03.124865+00:00
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