GnRH analogues in the treatment of endometriosis — rationale and efficacy
Endometriosis treatment for women aged 30-45 depends on disease factors and patient needs, with options including surgical or medical approaches.
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This chapter reviews the rationale and reported efficacy of gonadotrophin-releasing hormone (GnRH) analogues for treating endometriosis during the reproductive years, framing treatment as tailored to disease site, extent, symptoms, age, and childbearing goals and contrasting medical versus surgical approaches. It synthesizes evidence from prior clinical studies using different GnRH agonists and routes (e.g., depot, nasal, intranasal) and compares outcomes such as symptom control across regimens, including comparisons to danazol described in the cited literature. A major caveat emphasized in the chapter’s referenced background is that GnRH analogue–induced hypoestrogenism can lead to reversible hypogonadism and bone density loss, with skeletal effects discussed as an important limitation to efficacy-only interpretations. This paper is centrally about endometriosis — it specifically focuses on the rationale and efficacy of GnRH analogues as medical therapy.
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Cited by (12)
- Gonadotropin-releasing hormone analogues for endometriosis 2023
- Gonadotrophin-releasing hormone analogues for endometriosis 2021
- Medical and Surgical Management of Endometriosis 2018
- Medical Treatments for Endometriosis-Associated Pelvic Pain 2014
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 2010
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 2010
- Medical Management of Endometriosis 2006
- Gonadotropin-releasing hormone agonist treatment for endometriosis of the rectovaginal septum 2000
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
- Endometriosis, 1995 - confusion or sense? 1995
- A Risk Benefit Assessment of Drugs Used in the Treatment of Endometriosis 1994
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- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00