Endocrine Treatment of Endometriosis

In: Lasers in Gynecology · 1992 · pp. 125–130 · doi:10.1007/978-3-642-45683-1_16 · W120432906
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Endometriosis, characterized by ectopic endometrial tissue, causes pelvic pain and infertility, with medical treatment often administered after detection.

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This paper is a narrative overview of endocrine-based treatments for endometriosis, describing the disorder as ectopic endometrial tissue (often pelvic) and noting that symptomatic disease commonly involves dysmenorrhea, dyspareunia, and pain on vaginal examination, with endometriosis estimated to contribute to 10–20% of female infertility. It discusses that after diagnosis by laparoscopy or laparotomy, therapy may include surgical removal of implants or cysts, but medical endocrine treatment is commonly used, drawing on historical and mechanistic rationale involving agents such as GnRH analogs and danazol (including references to metabolic effects and bone mineral density concerns). A stated limitation is that the paper frames the field despite a large number of investigations: the pathogenesis remains unknown, which constrains how firmly treatment mechanisms can be tied to disease origin. This paper is centrally about endometriosis — it reviews endocrine treatment approaches (especially GnRH analog–based ovarian suppression and related therapies).

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Abstract

Endometriosis is one of the most common benign gynecological diseases, first described a century ago. Endometriosis is defined as ectopic endometrial tissue, usually located in the pelvis. In spite of a large number of investigations, the pathogenesis of this disorder has remained unknown. Symptomatic disease is characterized generally by pain (dysmenorrhea, dyspareunia, and pain on vaginal examination) and occasionally by a palpable mass (e.g., ovarian cysts). It is assumed that endometriosis accounts for 10%–20% of all female infertility. Presently, various therapeutic approaches can be taken, once the disease is detected by laparoscopy or laparotomy. Although the surgical removal of the implants or cysts is often attempted, medical treatment is usually administered. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

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Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 1992 Springer-Verlag Berlin Heidelberg About this chapter Cite this chapter Kiesel, L., Rabe, T., Runnebaum, B. (1992). Endocrine Treatment of Endometriosis. In: Bastert, G., Wallwiener, D. (eds) Lasers in Gynecology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45683-1_16 Download citation DOI: https://doi.org/10.1007/978-3-642-45683-1_16 Publisher Name: Springer, Berlin, Heidelberg Print ISBN: 978-3-642-45685-5 Online ISBN: 978-3-642-45683-1 eBook Packages: Springer Book Archive

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