GnRH agonists—antagonists — clinical applications
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This review discusses the clinical applications of gonadotropin-releasing hormone (GnRH) agonists and antagonists in managing various endocrine and reproductive conditions.
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Abstract
We know that there is a wide range of clinical applications for GnRH analogues in the field of benign gynaecological disorders. As we understand more of the physiology and mechanism of these GnRH agonists, and there appear more varied and perhaps efficient delivery systems, and antagonists become available, it may be possible to develop a graded approach in suppression of the hypothalamic pituitary axis. The true potential of these agents is then yet to be fully realized. There can be no doubt they are going to influence practice dramatically over the next decade. The potency of these agents, perhaps specifically their effects of oestrogen deficiency and calcium bone metabolism, suggests that limitation of duration of use and timing of recurrent administration to individuals is likely to be necessary.
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Too few in-corpus citations on either side for a chart; here are the lists.
Cites (3)
- “MEDICAL OOPHORECTOMY” USING A LONG-ACTING GNRH AGONIST-A POSSIBLE NEW APPROACH TO THE TREATMENT OF ENDOMETRIOSIS. 1982
- Intranasal treatment with luteinising hormone releasing hormone agonist in women with endometriosis. 1983
- Potential new treatment of endometriosis: reversible inhibition of pituitary-ovarian function by chronic intranasal administration of a luteinizing hormone-releasing hormone (LH-RH) agonist 1982
References (8)
- Intranasal treatment with luteinising hormone releasing hormone agonist in women with endometriosis. via openalex
- “MEDICAL OOPHORECTOMY” USING A LONG-ACTING GNRH AGONIST-A POSSIBLE NEW APPROACH TO THE TREATMENT OF ENDOMETRIOSIS. via openalex
- Potential new treatment of endometriosis: reversible inhibition of pituitary-ovarian function by chronic intranasal administration of a luteinizing hormone-releasing hormone (LH-RH) agonist via openalex
- W2060787751 via openalex
- W1529794801 via openalex
- W2477008945 via openalex
- W1913675875 via openalex
- W1997894565 via openalex
Source provenance
- europepmc
- last seen: 2026-09-27T09:11:36.575535+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:09:20.810540+00:00
License: CC0
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