The Use of GnRH Analogues to Control Menstrual Bleeding
Increased understanding of menstrual bleeding mechanisms has led to new approaches, such as GnRH analogues, to control excessive or disordered menstrual flow.
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This 1990 chapter reviews how improved understanding of the mechanisms regulating menstrual blood flow has led to new approaches for controlling excessive or disordered menstrual bleeding, focusing on the use of GnRH (LHRH) analogues to suppress reproductive endocrine activity. It discusses high-level evidence from physiological and primate studies and includes clinical experience with intranasal GnRH analogues, noting their effects on cyclic ovarian function and endometrium, and references work on uterine blood flow changes and treatment-related hypogonadism. A key limitation highlighted by the chapter context is that evidence spans different models and outcomes rather than providing a single, uniform controlled clinical result for all bleeding disorders. Relevance to endometriosis: the chapter cites prior work on intranasal LHRH agonist treatment in women with endometriosis (B M J 1983), though its main focus is broadly controlling menstrual bleeding with GnRH analogues.
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- Intranasal treatment with luteinising hormone releasing hormone agonist in women with endometriosis. via openalex
- PROSTAGLANDIN SYNTHESIS IN THE ENDOMETRIUM OF WOMEN WITH OVULAR DYSFUNCTIONAL UTERINE BLEEDING via openalex
- W2050568232 via openalex
- W2067663107 via openalex
- W2080318707 via openalex
- W2289796087 via openalex
- W2295442428 via openalex
- W2414394097 via openalex
- W2418754503 via openalex
- W1997894565 via openalex
- W4247840597 via openalex
- W2012521400 via openalex
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