The Use of GnRH Analogues to Control Menstrual Bleeding

In: GnRH Analogues in Reproduction and Gynecology · 1990 · pp. 49–60 · doi:10.1007/978-94-009-0721-8_7 · W1585295809
book-chapter OA: closed CC0
Full text JSON View on OpenAlex View at publisher
AI-generated summary by claude@2026-06+body, 2026-06-12

This paper discusses new approaches to control excessive or disordered menstrual bleeding, stemming from increased understanding of menstrual blood flow regulation mechanisms.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text

This chapter reviews how improved understanding of menstrual blood-flow regulation has enabled GnRH analogues to control excessive or disordered menstrual bleeding, summarizing mechanistic work on gonadotrophin suppression and uterine hormonal effects and citing related animal studies and early clinical reports. It discusses high-level evidence that chronic GnRH agonist exposure inhibits luteinizing hormone (and thus ovulation/ovarian cyclicity) and can alter endometrial patterns, with a stated limitation that some relevant findings come from nonhuman models and that therapy carries known systemic effects such as hypogonadism with potential impacts on bone density. It also includes examples such as intranasal LHRH agonist use in endometriosis and Doppler assessment of uterine blood-flow changes in fibroids, but the chapter’s focus remains menstrual bleeding control rather than endometriosis mechanistics. Relevance to endometriosis: the chapter explicitly cites intranasal LHRH agonist treatment in women with endometriosis (Shaw et al., 1983), though its main focus is controlling disordered menstrual bleeding using GnRH analogues.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 3,983 characters · extracted from oa-doi-fallback · 3 sections · click to expand

Abstract

A substantial proportion of General Practitioner consultations and gynaecological referrals concern disorders of menstrual bleeding. In the last decade an increased understanding of the mechanisms which initiate and regulate menstrual blood flow have resulted in new approaches to endeavour to control excessive or disordered menstrual bleeding. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

Markee, JE (1940). Menstruation in intraocular endometrial transplants in the rhesus monkey. Contr Embryol Cam Ins, 28, 219 Pickles, VR, and Hall, WJ (1963). Some physiological properties of the menstrual stimulant substances Al and A2. J Reprod Fertil, 6, 315 Abel, M (1979). Production of prostaglandins by the human uterus: are they involved in menstruation? Res Clinic Forums, 1, 33 Smith, SK, Abel, MH, Kelly, RW, and Baird, DT (1981). Prostaglandin synthesis in the endometrium of women with ovular dysfunctional uterine bleeding. Brit Obstet Gynaecol, 88, 434 Hamberg, M, and Samuellsson B (1974). Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc Natl Acad Sci USA, 71, 3400 Frser, HM, Laird, NC, and Blakeley, DM (1980). Decreased pituitary responsiveness and inhibition of the luteinizing hormone surge and ovulation in the stumptailed monkey (Macaca arrctoides) by chronic treatment with an agonist of luteinizing hormone-releasing hormone. Endocrinology, 115, 1780 Bergquist, C, Nillius, SJ, and Wide, L (1982). Long-term intranasal luteinizing hormone-releasing hormone agonist treatment for contraception in women. Fertil Steril, 38, 190 Schmidt-Gollwitzer, M, Hardt, W, Schmidt-Gollwitzer, K, Von der Ohne, M, and Nevinny-Stickel, J (1981). Influence of the LH-RH analogue buserelin on cyclic ovarian function and on endometrium. A new approach to fertility control? Contraception, 23, 187 Pedroza E, Vilchez-Martinez, JA, Coy, DH, Arimura, A, and Schally, AV (1978). Correlation between in vivo inhibition of gonadotrophin release induced by LHRH and the blockade of ovulation by synthetic analogues of LHRH. Int J Fertil, 23, 294 Frser, HM, and Shaw, RW (1984). Effects of chronic luteinizing hormone-releasing hormone agonist treatment in dysfunctional uterine bleeding in the stumptailed macaque. Acta Endocrinol, 106, 381 Bergquist, C, Nillius, SJ, Wide, L, and Lindgren, A (1981). Endometrial patterns in women on chronic luteinizing hormone-releasing hormone agonist treatment for contraception. Fertil Steril, 36, 339 Hallberg, L, and Nilsson, L (1964). Determination of menstrual blood loss. Scand J Clin Lab Invest, 16, 244 Shaw, RW, Fraser, HM, and Boyle, H (1983). Intranasal LHRH agonist treatment in women with endometriosis. Brit Med J, 287, 1667 Matta, WH, Shaw, RW, Hesp, R, and Katz, D (1987). Hypogonadism induced by luteinizing hormone releasing hormone agonist analogues: effects on bone density in pre-menopausal women. Brit Med J, 294, 1523 Matta, WH, Stabile, I, Shaw, RW, and Campbell, S (1988). Doppler assessment of uterine blood flow changes in patients with fibroids receiving the gonadotrophin-releasing hormone agonist buserelin. Fertil Steril (in press) Author information Authors and Affiliations Editor information Rights and permissions Copyright information © 1990 Kluwer Academic Publishers About this chapter Cite this chapter Shaw, R.W. (1990). The Use of GnRH Analogues to Control Menstrual Bleeding. In: Vickery, B.H., Lunenfeld, B. (eds) GnRH Analogues in Reproduction and Gynecology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0721-8_7 Download citation DOI: https://doi.org/10.1007/978-94-009-0721-8_7 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-010-6809-3 Online ISBN: 978-94-009-0721-8 eBook Packages: Springer Book Archive

Keywords

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (2)

References (16)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
unpaywall
last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0 · commercial use OK