The Use of GnRH Analogues to Control Menstrual Bleeding
This paper discusses new approaches to control excessive or disordered menstrual bleeding, stemming from increased understanding of menstrual blood flow regulation mechanisms.
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This chapter reviews how improved understanding of menstrual blood-flow regulation has enabled GnRH analogues to control excessive or disordered menstrual bleeding, summarizing mechanistic work on gonadotrophin suppression and uterine hormonal effects and citing related animal studies and early clinical reports. It discusses high-level evidence that chronic GnRH agonist exposure inhibits luteinizing hormone (and thus ovulation/ovarian cyclicity) and can alter endometrial patterns, with a stated limitation that some relevant findings come from nonhuman models and that therapy carries known systemic effects such as hypogonadism with potential impacts on bone density. It also includes examples such as intranasal LHRH agonist use in endometriosis and Doppler assessment of uterine blood-flow changes in fibroids, but the chapter’s focus remains menstrual bleeding control rather than endometriosis mechanistics. Relevance to endometriosis: the chapter explicitly cites intranasal LHRH agonist treatment in women with endometriosis (Shaw et al., 1983), though its main focus is controlling disordered menstrual bleeding using GnRH analogues.
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- Intranasal treatment with luteinising hormone releasing hormone agonist in women with endometriosis. via openalex
- PROSTAGLANDIN SYNTHESIS IN THE ENDOMETRIUM OF WOMEN WITH OVULAR DYSFUNCTIONAL UTERINE BLEEDING via openalex
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