The effect of LHRH agonist therapy in the treatment of endometriosis (English experience).
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Buserelin and danazol both reduced endometriosis lesion severity by modified AFS scores after seven months, with danazol causing more adverse effects.
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Abstract
The preliminary findings of a comparative study of buserelin and danazol in the treatment of endometriosis are presented. Eighty patients with laparoscopically proven symptomatic endometriosis have been allocated at random to open treatment with intra-nasal buserelin or oral danazol. Forty-five patients have been assessed after completion of seven months treatment. Changes in endometriotic lesions have been examined by second laparoscopy and scored according to a modification of the criteria of the American Fertility Society (AFS). Both treatments were associated with reductions in modified AFS scores reflecting partial resolution of the condition. Adverse effects were reported with the use of both drugs, but appeared to be more extensive during therapy with danazol. Further evaluation and post treatment follow up are required.
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Cited by (9)
- Gonadotropin-releasing hormone analogues for endometriosis 2023
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 2010
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
- Today's treatments: how do you choose? 1999
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 1999
- 7 Endometriosis and pelvic pain 1993
- Laser laparoscopy—indications, techniques and results 1993
- Laser laparoscopy in the treatment of endometriosis 1991
- GnRH Analogues in the Treatment of Endometriosis 1989
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- europepmc
- last seen: 2026-06-13T06:22:48.782012+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:09:40.384591+00:00
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