Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits

Rogério Saad-Hossne, Adriana Beatriz Barretto, Juliana Menezes Siqueira, Rafael Denadai
Acta cirurgica brasileira · 2016 · vol. 31(4) , pp. 227–234 · doi:10.1590/s0102-865020160040000002 · PMID:27168534 · W2378958921
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Intralesional 20% aspirin injection in rabbits experimentally induced with peritoneal endometriosis resulted in significant reduction and total destruction of endometriosis foci compared to saline controls.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This study evaluated whether intralesional injection of 20% acetylsalicylic acid (aspirin) could treat experimentally induced peritoneal endometriosis in 40 adult female rabbits, using a double-blind randomized controlled design. After lesions were induced and treated at postoperative day 30, histopathology (qualitative necrosis/hemorrhage/inflammation/apoptosis and quantitative remaining endometriotic area) was assessed at 10 and 20 days post-treatment, with saline-injected controls. Aspirin-treated rabbits showed extensive necrosis, hemorrhage, apoptosis, and fibrosis, with significantly smaller remaining endometriosis areas and sparse or absent endometrial tissue foci at both time points; saline controls maintained typical endometrial tissue cysts. The paper’s main caveat is that efficacy is demonstrated only in a rabbit peritoneal endometriosis model, with outcomes measured histologically rather than assessing clinical endpoints; This paper is centrally about endometriosis — it tests intralesional 20% aspirin injection for cytodestruction of peritoneal endometriosis foci in rabbits.

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Abstract

PURPOSE: To investigate the efficacy of intralesional 20% aspirin injection for treatment of experimental peritoneal endometriosis. METHODS: Peritoneal endometriosis was experimentally induced in forty adult nulligravid female rabbits. On day 30 post-endometriosis induction, rabbits were randomly divided to assess early (10 days) and late (20 days) effects of intralesional injection of physiological saline solution (control groups) in comparison to intralesional injection of 20% bicarbonate aspirin solution (experimental groups) as follows: control group 1 (10 days, n=10); control group 2 (20 days, n=10); experimental group 3 (10 days, n=10); experimental group 4 (20 days, n=10). Resected tissues, including endometriosis foci, were qualitatively (general morphology and signs of inflammatory cells infiltrate, necrosis and apoptosis) and quantitatively (remaining endometriosis area) assessed by histopathological analysis. RESULTS: Extensive necrosis, hemorrhage, apoptosis, and fibrosis were observed in the experimental groups 3 and 4. Groups 1 and 2 presented typical endometrial tissue cysts, respectively. Groups 3 and 4 showed sparse endometrial tissue foci and no endometrial tissue, respectively. Quantitative analysis revealed that aspirin-treated groups 3 and 4 had significantly (p<0.05) smaller remaining endometriosis area, compared to control groups 1 and 2. CONCLUSION: Intralesional 20% aspirin injection caused total destruction of peritoneal endometriosis foci in rabbits.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Aspirin Cyclooxygenase Inhibitors Endometriosis Injections, Intralesional Peritoneal Diseases Animals Anti-Inflammatory Agents Anti-Inflammatory Agents Apoptosis Aspirin Cyclooxygenase Inhibitors Disease Models, Animal Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Peritoneal Diseases Peritoneal Diseases

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