The effect of leflunomide on the transplanted endometriosis lesions in SD rats

Jing Yang, J J Yang, Yi Gao, Y Gao, Y H Wang, C H Wang, L K Wang, L.D. Wang, Bei‐Lei Tao, B B Tao, Hui Guo, H F Guo, S G Ding, Shuai Ding, A H Wu, Amanda Wu, Guojie Zhai, G R Zhai, X M Feng, Xueliang Feng
Clinical and experimental obstetrics & gynecology · 2017 · vol. 44(1) , pp. 129–132 · doi:10.12891/ceog3148.2017 · PMID:29714881 · W3024892756
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

Leflunomide treatment significantly reduced the size of transplanted endometriosis lesions and TGF-β1 expression in SD rats compared to saline treatment.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

This study evaluated leflunomide’s effects on surgically induced, transplanted endometriosis lesions in SD rats, measuring lesion focal volume and transforming growth factor (TGF)-β1 expression via immunohistochemistry after three weeks of treatment. Rats were allocated to a normal saline control and a leflunomide-treated group (35 mg·kg−1·d−1), and lesion volume and TGF-β1 gray values were compared across groups. Leflunomide significantly reduced lesion focal volume relative to pre-treatment values and produced smaller volumes than saline controls, alongside lower TGF-β1 gray values. The paper frames this as therapeutic potential but is limited to an animal transplanted endometriosis model and includes no discussion of longer-term outcomes or broader mechanistic endpoints beyond TGF-β1. This paper is centrally about endometriosis — it tests leflunomide effects on transplanted endometriosis lesion size and TGF-β1 levels in rats.

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Abstract

OBJECTIVE: To investigate the effects of the leflunomide (LEF) on the size of the transplanted endometriosis (EMS) lesions and trans- forming growth factor (TGF) -β1gray level in SD rats. MATERIALS AND METHODS: EMS was surgically induced in rats by autologous trans- plantation and the focal volume was also measured. The rats were divided into three groups: group A: normal SD rats, group B: rats irrigated by one ml-kg⁻¹d⁻¹ saline for three weeks, and group C: rats irrigated by 35 mg-kg⁻¹d⁻¹ LEF for three weeks. The rats were then sacrificed and measured their focal volume and TGF-β1 gray value with immunohistochemical method. RESULTS: The sizes of the focal volume in group C were significantly reduced compared to the rats before feeding, and the volume in group C was smaller than group B after feeding and so was the TGF-β1. CONCLUSION: LEF could be a new therapeutic drug for EMS.
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Abstract

Objective: To investigate the effects of the leflunomide (LEF) on the size of the transplanted endometriosis (EMS) lesions and transforming growth factor (TGF) -β1gray level in SD rats. Materials and Methods: EMS was surgically induced in rats by autologous transplantation and the focal volume was also measured. The rats were divided into three groups: group A: normal SD rats, group B: rats irrigated by one ml·kg-1·d-1 saline for three weeks, and group C: rats irrigated by 35 mg·kg-1·d-1 LEF for three weeks. The rats were then sacrificed and measured their focal volume and TGF-β1 gray value with immunohistochemical method. Results: The sizes of the focal volume in group C were significantly reduced compared to the rats before feeding, and the volume in group C was smaller than group B after feeding and so was the TGF-β1. Conclusion: LEF could be a new therapeutic drug for EMS.

Keywords

- Ectopic endometriosis model in rats - Endometriosis - Leflunomide - TGF-β1

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Immunosuppressive Agents Isoxazoles Animals Endometriosis Endometriosis Female Immunosuppressive Agents Isoxazoles Leflunomide Rats, Sprague-Dawley Transforming Growth Factor beta1 Transforming Growth Factor beta1

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (13)

Cited by (3)

SciLite annotations

chemicals 2
leflunomide leflunomide
organisms 5
rattus sp. rattus sp. rattus sp. rattus sp. rattus sp.

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