Tratamiento de la endometriosis con 5mg o 25mg diarios de mifepristona durante 6 meses. Ensayo clínico aleatorizado, doble ciego

Josep Lluís Carbonell Esteve, Orlando Perera Boza, Ana María Riverón Cobo, J. González, Giuseppe Tomasi
In: Progresos de Obstetricia y Ginecología · 2011 · vol. 55(2) , pp. 51–59 · doi:10.1016/j.pog.2011.09.005 · W2092266262
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This randomized, double-blind study found that 5 mg and 25 mg daily doses of mifepristone significantly reduced dysmenorrhea and dyspareunia in women with endometriosis over six months.

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Abstract

Evaluar la eficacia y seguridad de 5 y 25 mg de mifepristona en el tratamiento de la endometriosis. Ensayo clínico aleatorizado, doble ciego. Hospital Eusebio Hernández, La Habana, Cuba. Veintiséis mujeres con diagnóstico laparoscópico de endometriosis. Grupo I: una tableta oral diaria de 25 mg de mifepristona, o grupo II: una tableta oral diaria de 5 mg de mifepristona, durante 6 meses. Se realizó laparoscopia y biopsia endometrial pre y postratamiento. Reducción de la intensidad de la dismenorrea medida por una escala visual análoga. En ambos grupos las disminuciones de la intensidad de la dismenorrea y la dispareunia fueron muy significativas comparadas con los valores iniciales. Todas las mujeres estaban en amenorrea a los 45 días de tratamiento. La mifepristona, en dosis de 25 o 5 mg, podría ser una alternativa para el tratamiento de la endometriosis. To evaluate the safety and efficacy of 5 mg and 25 mg doses of mifepristone for the treatment of endometriosis. Randomized double-blind study. Eusebio Hernández Hospital, Havana, Cuba. Twenty-six women laparoscopically diagnosed with endometriosis were included. Group I received one tablet of 25 mg mifepristone daily and group II received one tablet of 5 mg mifepristone daily for 6 months. Laparoscopy and endometrial biopsy were performed before and after treatment. Reduction in the intensity of dysmenorrhea measured by a visual analogue scale. In both groups reductions in the intensity of dysmenorrhea and dyspareunia were highly significant compared with initial values (P <.001). All the women were amenorrheic after 45 days of treatment. At doses of 5 mg or 25 mg, mifepristone could be an alternative for the treatment of endometriosis.

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Condition tags

endometriosisdysmenorrheadyspareunia

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