Report on Repeated Mifepristone Treatment for Uterine Fibroids or Endometriosis

Josep Lluís Carbonell Esteve, Rita Acosta, Yasmirian Pérez, Riveron Ana Maria, Gonzalez Jesus, Carlos Sanchez, Giuseppe Tomasi
In: Journal of Clinical Gynecology and Obstetrics · 2013 · vol. 2(1) , pp. 31–37 · doi:10.4021/jcgo.v2i1.171 · W2076767069
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Abstract

Background: No information is available on how repeated administration of mifepristone could affect women ’ s health. Methods: A total of 101 and 36 subjects who participated in up to 2 and 3 mifepristone trials to treat endometriosis or uterine fibroids, respectively, carried out at the “ Eusebio Hernandez ” Hospital, Havana, Cuba. Results: Subjects who repeated mifepristone to treat fibroids did so for 7.3 ± 2.5 months, minimum and maximum of 6 and 15 months, respectively. The average rest interval was 9.7 ± 6.2 months, minimum and maximum of 3 and 30 months, respectively. In subjects repeating mifepristone for endometriosis, the average was 18 ± 2.0, with a minimum and maximum of 12 and 24 months, respectively. The average rest interval was 8.3 ± 5.3 months, 95% CI = 7.6 - 8.9, minimum and maximum of 3 and 30 months, respectively. No change in women ’ s health was detected months after termination of final mifepristone treatment. Conclusions: Repeating low doses mifepristone treatment up to 3 - 4 times for 3, 6 or 9 months duration with variable rest intervals between sessions, did not seem to involve any risk to health. More studies to confirm the long-term safety of repeated low dosage mifepristone are mandatory. doi: http://dx.doi.org/10.4021/jcgo148e

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endometriosis

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