Treatment of endometriosis with cyproterone acetate. Preliminary report

C Morán, Carlos Morán, Morán C, Alcivia JC, J C Alcivia, Juan Carlos Alcivia, E García-Hernández, García-Hernández E, Castro J, J Castro
Archives of medical research · 1996 · vol. 27(4) , pp. 535–8 · PMID:8987191 · W71247536
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Cyproterone acetate treatment for six months improved dysmenorrhea and reduced endometriosis severity in seven patients, though it caused menstrual disorders and minimal changes in hirsutism.

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Abstract

The objective of this work was to evaluate the effectiveness of cyproterone acetate for the treatment of endometriosis. Seven patients with dysmenorrhea due to endometriosis and idiopathic hirsutism were included. Endometriosis was laparoscopically classified as minimal in two cases, mild in two, moderate in two and severe in one patient. Cyproterone acetate was initiated at a daily dose of 10 mg orally for 20 days, followed by 10 days without medication. This sequence was repeated over a period of 6 months. Dysmenorrhea improved in all study subjects. Menstrual disorders were observed in all women, with oligomenorrhea in six patients and spotting in one. At the end of treatment, a second look laparascopy revealed minimal endometriosis in five patients and no evidence of the disease in the other two cases. Hirsutism was slightly reduced in two patients and without changes in the other five. These preliminary data disclose the possible therapeutic use of cyproterone acetate in endometriosis.

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Condition tags

dysmenorrheaendometriosis

MeSH descriptors

Cyproterone Acetate Dysmenorrhea Endometriosis Hirsutism Progesterone Congeners Administration, Oral Administration, Oral Adolescent Adolescent Adult Adult Clinical Trials as Topic Clinical Trials as Topic Cyproterone Acetate Cyproterone Acetate Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (10)

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