Pathogenese der Endometriose und Wirkungsmechanismus der Hormontherapie

Ludwig Kiesel, B. Runnebaum
In: Leuprorelinacetat — Ein neues GnRH-Analogon · 1992 · pp. 11–26 · doi:10.1007/978-3-642-77666-3_2 · W1022117212
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-12 ⓘ

Endometrial tissue in endometriosis differs morphologically from normal endometrium, exhibiting lower and less cycle-dependent steroid receptor concentrations, and shows variable responses to hormonal manipulation.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The paper discusses the pathogenesis of endometriosis in women of reproductive age by contrasting ectopic endometriotic tissue with eutopic endometrium, focusing on differences in steroid receptor concentrations and cycle dependence. It explains that although endometriotic tissue is sex-hormone dependent, it does not always respond to hormone administration or withdrawal in the same way as normal endometrium, and it frames these differences as central to how hormonal therapies work. The authors emphasize mechanistic aspects of hormone action, but the provided text does not include specific experimental details or results beyond these tissue-level differences. This paper is centrally about endometriosis — it reviews mechanisms of endometriosis pathogenesis and the hormonal therapy mechanism.

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Zusammenfassung Die Endometriose ist eine Erkrankung von Frauen im reproduktiven Alter. Unter Endometriose versteht man die Heterotopie von Gebärmutterschleimhaut. Ektopes endometriotisehes Gewebe unterscheidet sich morphologisch jedoch erheblich von eutoper Schleimhaut (Schweppe u. Wynn 1984; Schweppe et al. 1981), so ist beispielsweise die Konzentration von Steroidrezeptoren im Zytosol der Zellen aus Endometrioseherden insgesamt niedriger und außerdem weit weniger zyklusabhängig. Endometriotisehes Gewebe — obwohl geschlechtshor- monabhängig — reagiert nicht immer genauso wie Endometrium auf Hormonzufuhr oder -entzug. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others Literatur Brosens IA, Koninckx PR, Corveleyn PA (1978) A study of plasma progesterone, oestradiol-17β, prolaktin and LH levels, and of the luteal phase appearance of the ovaries in patients with endometriosis and infertility. Br J Obstet Gynaecol 85: 246–250 Buttram VC (1979a) Conservative surgery for endometriosis in the infertile female: a study of206 patients with implications for both medical and surgical therapy. Fertil Steril 31: 117–123 Buttram VC (1979b) Surgical treatment of endometriosis in the infertile female: a modified approach. Fertil Steril 32: 635–640 Clayton RN, Catt KJ (1981) Gonadotropin-releasing hormone receptors: charcterization, physiological regulation and relationship to reproductive function. Endocr Rev 2: 186–209 Cullen TS (1908) Adenomyoma of the uterus. Saunders, Philadelphia DiZerega GS, Barber DL, Hodgen GD (1980) Endometriosis: role of ovarian steroids in initiation, maintenance and suppression. Fertil Steril 33: 649–653 Halban J (1925) Hysteroadenosis metastatica. Die lymphogene Genese der sog. Adenofibromatosis heterotopica. Arch Gynäkol 124: 457–482 Helm K, Kiesel L, Rabe T, Runnebaum B (1988) Desensitization of pituitary ceils by gonadotropin-releasing hormone in vitro. In: Runnebaum B, Rabe T, Kiesel L (eds) Female contraception. Springer, Berlin, Heidelberg New York Tokyo, pp 184–191 Huckle WR, Conn PM (1987) The relationship between gonadotropin-releasing hormone-stimulated luteinizing hormone release and inositol phosphate production: studies with calcium antagonists and proteinkinase C activators. Endocrinology 120: 160–169 Iwanof NF (1898) Drüsiges cystenhaltiges Uterusfibrom, kompliziert durch Sarkom und Karzinom. Monatsschr Geburtshilfe 7: 295–300 Javert CT (1949) Pathogenesis of endometriosis based on endometrial homeoplasia, direct extension, exfoliation and implantation, lymphatic and hematogenous metastasis. Cancer 2: 399–410 Kiesel L, Runnebaum B (1990a) Mechanisms involved in the hormonal treatment of endometriosis. In: Chadha DR, Buttram VC Jr. Current concepts in endometriosis. Alan R. Liss, New York pp 179–196 Kiesel L, Runnebaum B (1990b) Neuroendocrine mechanisms of gonadotropin releasing hormone action. In: Brosens I, Jacobs HS, Runnebaum B (eds) LHRH analogues in gynaecology. Parthenon, New Jersey, pp 7–16 Kiesel L, Bertges K, Rabe T, Runnebaum (1986) Gonadotropin-releasing hormone enhances polyphosphoinositide hydrolysis in rat pituitary cells. Biochem Biophys Res Commun 134: 861–867 Kiesel L, Lukàcs GL, Eberhardt I, Runnebaum B, Spät A (1987a) Effect of inositol 1,4,5-triphosphate and GTP on calcium release from pituitary microsomes. FEBS Lett 217: 85–88 Kiesel L, Przylipiak A, Rabe T, Runnebaum B (1987b) Leukotrienes stimulate gonadotropin-release in vitro. Gynecol Endocrinol 1: 25–35 Kiesel L, Rabe T, Helm K, Maier C, Runnebaum B (1988) Potency of contraceptive progestins to inhibit luteinizing hormone secretion in vitro. In: Runnebaum B, Rabe T, Kiesel L (eds) Female contraception. Springer, Berlin, Heidelberg New York Tokyo, pp 192–205 Kistner RW (1980) Endometriosis. In: Sciarra J (ed) Gynecology and obstetrics, vol 1/38. Harper & Row, Hagerstown, pp 1–44 Meyer R (1919) Über den Stand der Frage derAdenomyositis und Adenomyome im allgemeine und insbesondere über Adenomyositis serosoepithelialis und Adenomymetritis sarcomatosa. Zentrabi Gynäkol 43: 745–750 Nishizuka Y (1984) The role of proteinkinase C in cell surface signal transduction and tumor promotion. Nature 308: 693–698 Prakash S, Ulfelder H, Cohen RB (1965) Enzyme- histochemical observations on endometriosis. Am J Obstet Gynecol 91: 990–997 Sampson JA (1921) Perforating hemorrhagic (chocolate) cysts of the ovary, their importance and especially their relation to pelvic adenomas of the endometrial type. Arch Surg 3: 245–323 Sampson JA (1927) Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into peritoneal cavity. Am J Obstet Gynecol 14: 422–469 Scott RB, Wharton LR (1957) The effect of estrone and progesterone on the growth of experimental endometriosis in rhesus monkeys. Am J Obstet Gynecol 74: 852–865 Smith MA, Vale WW (1981) Desensitization of gonadotropin-releasing hormone observed in superfused pituitary cells on cytodex beads. Endocrinology 108: 752–759 Schweppe KW, Wynn RM (1984). Endocrine dependency of endometriosis: an ultrastructural study. Eur J Obstet Gynecol Reprod Biol 17: 193–208 Schweppe KW, Dmowski WP, Wynn RM (1981) Ultrastructural changes in endometriotic tissue during danazol treatment. Fertil Steril 36: 20–26 Vanderhoek JY, Kiesel L, Naor Z, Bailey JM, Catt KJ (1984) Arachidonic acid metabolism in gonadotroph-enriched pituitary cells. Prostaglandins Leukotrienes Med 15: 375–385 Vierikko P, Kauppilla A, Rönneberg L (1985) Steroidal regulation of endometriosis tissue: lack of induction of 17-β-hydroxysteroiddedydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol Fertil Steril 43: 218 Waldeyer (1870) Eierstock und Ei. Leipzig. Zit. nach Gondall JR (1944) A study of endometriosis 2nd edn. Lippincott, Philadelphia, p 2 Wildt L (1987) Die endokrine Kontrolle des menstruellen Zyklus. In: Diedrich K (Hrsg) neue Wege in Diagnostik und Therapie der weiblichen Sterilität. Enke, Stuttgart, S 1–25 Editor information Editors and Affiliations Rights and permissions Copyright information © 1992 Springer-Verlag Berlin Heidelberg About this paper Cite this paper Kiesel, L., Runnebaum, B. (1992). Pathogenese der Endometriose und Wirkungsmechanismus der Hormontherapie. In: Runnebaum, B., Breckwoldt, M. (eds) Leuprorelinacetat — Ein neues GnRH-Analogon. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77666-3_2 Download citation DOI: https://doi.org/10.1007/978-3-642-77666-3_2 Publisher Name: Springer, Berlin, Heidelberg Print ISBN: 978-3-540-55721-0 Online ISBN: 978-3-642-77666-3 eBook Packages: Springer Book Archive

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