Endometriosis – hormones and treatment

Patrycja Obrycka, Julia Soczyńska, Wiktor Gawełczyk, Paulina Tomecka, Paul Mozdziak
In: Medical Journal of Cell Biology · 2024 · vol. 12(2) , pp. 54–60 · doi:10.2478/acb-2024-0008 · W4403024387
article OA: diamond CC0 ⤵ 1 in-corpus citation
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This paper reviews endometriosis, a condition affecting 10-15% of women, its symptoms, diagnosis, hormonal influences, and current treatment approaches focusing on pain management and hormonal therapy.

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Abstract

Abstract Endometriosis is a prevalent condition, affecting 10-15% of women of reproductive age and approximately 70% of those with chronic pelvic pain. An estimated 176 million women worldwide are affected by this disease. The condition occurs predominantly between menarche and menopause, with peak incidence between the ages of 25 and 45. Endometriosis is characterized by the presence of endometrial-like tissue outside the uterine cavity, leading to the formation of lesions most commonly in the ovaries but also in the fallopian tubes, gastrointestinal tract, and occasionally in distant locations like the pleura and central nervous system. Symptoms include chronic pelvic pain, heavy and painful menstrual periods, dyspareunia, painful urination, and defecation. Diagnosis involves a combination of medical history, physical examination, imaging techniques, and the gold standard, diagnostic laparoscopy. There is an average delay of 6.7 years between symptom onset and diagnosis, often due to variable and confusing symptoms resembling other conditions. The pathogenesis of endometriosis involves genetic, hormonal, and environmental factors, with significant roles played by estrogens and progesterone. Treatment strategies focus on managing symptoms through pain relief, hormonal therapy, and surgical interventions, although no permanent cure exists. Hormonal imbalances, particularly the interaction of progesterone and estrogens, play a crucial role in disease progression. Current research explores various treatment options, including hormonal therapy, nonsteroidal anti-inflammatory drugs, antioxidants, and surgical methods to improve the quality of life for patients.

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Condition tags

endometriosischronic_pelvic_paindyspareunia

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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