A possible mechanism of action of danazol and an ethinylestradiol/ norgestrel combination used as postcoital contraceptive agents

Sam Rowlands; Ali A. Kubba; John Guillebaud; W Bounds

doi:10.1016/0010-7824(86)90042-9

A possible mechanism of action of danazol and an ethinylestradiol/ norgestrel combination used as postcoital contraceptive agents

Sam Rowlands, Ali A. Kubba, John Guillebaud, W Bounds

In: Contraception · 1986 · vol. 33(6) , pp. 539–545 · doi:10.1016/0010-7824(86)90042-9 · PMID:3533419 · W2096509487

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This paper investigated the mechanism of action for danazol and an ethinylestradiol/norgestrel combination when used as postcoital contraceptive agents.

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Abstract

Twenty-seven women requesting postcoital contraception were randomly allocated to take an ethinylestradiol/dl-norgestrel combination or danazol. Urine specimens were assayed for luteinising hormone (LH) and pregnanediol-3-glucuronide (P3G) levels from the day of the postcoital treatment to the next period. In addition, the urine samples of these recruits and 12 additional women were assayed for the Beta-subunit of human chorionic gonadotropin (B-hCG). A consistent pattern of alteration in urinary steroids was lacking, indicating a heterogeneous effect on ovarian function. There was no evidence of early pregnancy in successfully treated cases. We suggest that the main mechanism of action of these drugs is at the endometrial level.

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References (24)

Danazol Suppresses Luteal Function in Vitro and in Vivo via openalex
Endocrine effects of danazol in the treatment of endometriosis via openalex
Post-Coital Contraception with Danazol, Compared with an Ethinyloestradiol—Norgestrel Combination or Insertion of an Intra-Uterine Device via openalex
Review: The Mechanism of Action of Danazol, a Novel Steroid Derivative via openalex
Side effects of danazol compared with an ethinyloestradiol/norgestrel combination when used for postcoital contraception via openalex
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doi:10.1016/0010-7824(74)90041-9 via openalex
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doi:10.1016/0010-7824(77)90042-7 via openalex
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doi:10.1016/s0015-0282(16)39488-2 via openalex
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License: CC0 · commercial use OK

[1] Danazol Suppresses Luteal Function in Vitro and in Vivo via openalex

[2] Endocrine effects of danazol in the treatment of endometriosis via openalex

[3] Post-Coital Contraception with Danazol, Compared with an Ethinyloestradiol—Norgestrel Combination or Insertion of an Intra-Uterine Device via openalex

[4] Review: The Mechanism of Action of Danazol, a Novel Steroid Derivative via openalex

[5] Side effects of danazol compared with an ethinyloestradiol/norgestrel combination when used for postcoital contraception via openalex

[6] doi:10.1016/s0015-0282(16)45256-8 via openalex

[7] doi:10.1016/0010-7824(74)90041-9 via openalex

[8] doi:10.1210/jcem-29-7-904 via openalex

[9] doi:10.1210/jcem-36-3-615 via openalex

[10] W2396002016 via openalex

[11] W4285719527 via openalex

[12] doi:10.1016/0002-9378(66)90676-4 via openalex

[13] doi:10.1016/s0015-0282(16)47413-3 via openalex

[14] doi:10.1016/s0015-0282(16)42191-6 via openalex

[15] doi:10.1016/s0015-0282(16)42793-7 via openalex

[16] doi:10.1016/s0015-0282(16)44237-8 via openalex

[17] doi:10.1016/0010-7824(77)90042-7 via openalex

[18] doi:10.1016/0010-7824(75)90048-7 via openalex

[19] doi:10.1530/acta.0.0680779 via openalex

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[21] doi:10.1016/s0015-0282(16)47422-4 via openalex

[22] doi:10.1016/0002-9378(81)90611-6 via openalex

[23] doi:10.1016/s0015-0282(16)39488-2 via openalex

[24] doi:10.1016/s0015-0282(16)46874-3 via openalex