A possible mechanism of action of danazol and an ethinylestradiol/norgestrel combination used as postcoital contraceptive agents

Sam Rowlands; S Rowlands; Ali A. Kubba; A A Kubba; John Guillebaud; J Guillebaud; W Bounds

doi:10.1016/0010-7824(86)90042-9

A possible mechanism of action of danazol and an ethinylestradiol/norgestrel combination used as postcoital contraceptive agents

Sam Rowlands, S Rowlands, Ali A. Kubba, A A Kubba, John Guillebaud, J Guillebaud, W Bounds

Contraception · 1986 · vol. 33(6) , pp. 539–545 · doi:10.1016/0010-7824(86)90042-9 · PMID:3533419 · W2096509487

RCT OA: closed CC0 ⤵ 5 in-corpus citations

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This paper investigated the mechanism of action for danazol and an ethinylestradiol/norgestrel combination when used as postcoital contraceptive agents.

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Abstract

Twenty-seven women requesting postcoital contraception were randomly allocated to take an ethinylestradiol/dl-norgestrel combination or danazol. Urine specimens were assayed for luteinising hormone (LH) and pregnanediol-3-glucuronide (P3G) levels from the day of the postcoital treatment to the next period. In addition, the urine samples of these recruits and 12 additional women were assayed for the Beta-subunit of human chorionic gonadotropin (B-hCG). A consistent pattern of alteration in urinary steroids was lacking, indicating a heterogeneous effect on ovarian function. There was no evidence of early pregnancy in successfully treated cases. We suggest that the main mechanism of action of these drugs is at the endometrial level.

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MeSH descriptors

Contraceptives, Postcoital Contraceptives, Postcoital, Synthetic Danazol Ethinyl Estradiol Norgestrel Pregnadienes Chorionic Gonadotropin Chorionic Gonadotropin Clinical Trials as Topic Contraceptives, Postcoital Contraceptives, Postcoital, Synthetic Danazol Endometrium Endometrium Ethinyl Estradiol Ethinyl Estradiol-Norgestrel Combination Female Humans Luteinizing Hormone Luteinizing Hormone

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References (24)

Danazol suppresses luteal function in vitro and in vivo via openalex
Endocrine effects of danazol in the treatment of endometriosis via openalex
Post-Coital Contraception with Danazol, Compared with an Ethinyloestradiol—Norgestrel Combination or Insertion of an Intra-Uterine Device via openalex
Review: The mechanism of action of danazol, a novel steroid derivative via openalex
Side effects of danazol compared with an ethinyloestradiol/norgestrel combination when used for postcoital contraception via openalex
doi:10.1016/s0015-0282(16)45256-8 via openalex
doi:10.1016/0010-7824(74)90041-9 via openalex
doi:10.1210/jcem-29-7-904 via openalex
doi:10.1210/jcem-36-3-615 via openalex
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doi:10.1016/0002-9378(66)90676-4 via openalex
doi:10.1016/s0015-0282(16)47413-3 via openalex
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doi:10.1016/s0015-0282(16)42793-7 via openalex
doi:10.1016/s0015-0282(16)44237-8 via openalex
doi:10.1016/0010-7824(77)90042-7 via openalex
doi:10.1016/0010-7824(75)90048-7 via openalex
doi:10.1530/acta.0.0680779 via openalex
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Cited by (5)

Danazol 2022
In support of emergency contraception 1999
Research on new methods of emergency contraception 1996
Post coital contraception 1993
Post-coital contraception: an overview of published studies 1989

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License: CC0 · commercial use OK

[1] Danazol suppresses luteal function in vitro and in vivo via openalex

[2] Endocrine effects of danazol in the treatment of endometriosis via openalex

[3] Post-Coital Contraception with Danazol, Compared with an Ethinyloestradiol—Norgestrel Combination or Insertion of an Intra-Uterine Device via openalex

[4] Review: The mechanism of action of danazol, a novel steroid derivative via openalex

[5] Side effects of danazol compared with an ethinyloestradiol/norgestrel combination when used for postcoital contraception via openalex

[6] doi:10.1016/s0015-0282(16)45256-8 via openalex

[7] doi:10.1016/0010-7824(74)90041-9 via openalex

[8] doi:10.1210/jcem-29-7-904 via openalex

[9] doi:10.1210/jcem-36-3-615 via openalex

[10] W2396002016 via openalex

[11] W4285719527 via openalex

[12] doi:10.1016/0002-9378(66)90676-4 via openalex

[13] doi:10.1016/s0015-0282(16)47413-3 via openalex

[14] doi:10.1016/s0015-0282(16)42191-6 via openalex

[15] doi:10.1016/s0015-0282(16)42793-7 via openalex

[16] doi:10.1016/s0015-0282(16)44237-8 via openalex

[17] doi:10.1016/0010-7824(77)90042-7 via openalex

[18] doi:10.1016/0010-7824(75)90048-7 via openalex

[19] doi:10.1530/acta.0.0680779 via openalex

[20] doi:10.1016/0002-9378(73)90625-x via openalex

[21] doi:10.1016/s0015-0282(16)47422-4 via openalex

[22] doi:10.1016/0002-9378(81)90611-6 via openalex

[23] doi:10.1016/s0015-0282(16)39488-2 via openalex

[24] doi:10.1016/s0015-0282(16)46874-3 via openalex