Side effects of danazol compared with an ethinyloestradiol/norgestrel combination when used for postcoital contraception
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This study compared the side effects of danazol with an ethinyloestradiol/norgestrel combination used for postcoital contraception.
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Abstract
A postcoital contraceptive with a lower incidence of nausea and vomiting than oestrogen-progestogen combinations would be a significant advance. During a nine-month period, 101 women were treated at the Margaret Pyke Centre in London with either an oestrogen-progestogen combination or with danazol. A comparison of the side effects of each drug is reported. Those treated with danazol were six times less likely to experience nausea and none vomited. With the exception of breast symptoms, other side effects were five times less common in women receiving danazol. These differences give danazol a clear advantage in terms of patient acceptability. Further experience will enable the efficacy of danazol to be evaluated and so determine whether this drug should become the preferred hormonal postcoital treatment.
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Cited by (8)
- Effect of post‐coital contraceptive methods on the endometrium and the menstrual cycle 1996
- Research on New Methods of Emergency Contraception 1996
- Post coital contraception 1993
- Comparison of Yuzpe regimen, danazol, and mifepristone (RU486) in oral postcoital contraception. 1992
- Alternative treatments in oral postcoital contraception: interim results 1991
- Hormonal postcoital contraception with an ethinylestradiol-norgestrel combination and two danazol regimens 1990
- Post-coital contraception: An overview of published studies 1989
- A possible mechanism of action of danazol and an ethinylestradiol/ norgestrel combination used as postcoital contraceptive agents 1986
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