Side effects of danazol compared with an ethinyloestradiol/norgestrel combination when used for postcoital contraception

S Rowlands, Sam Rowlands, John Guillebaud, J Guillebaud, W Bounds, M Booth, Margaret Booth
Contraception · 1983 · vol. 27(1) , pp. 39–49 · doi:10.1016/0010-7824(83)90054-9 · PMID:6839757 · W1971394632
RCT OA: closed CC0 ⤵ 8 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study compared the side effects of danazol with an ethinyloestradiol/norgestrel combination used for postcoital contraception.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

A postcoital contraceptive with a lower incidence of nausea and vomiting than oestrogen-progestogen combinations would be a significant advance. During a nine-month period, 101 women were treated at the Margaret Pyke Centre in London with either an oestrogen-progestogen combination or with danazol. A comparison of the side effects of each drug is reported. Those treated with danazol were six times less likely to experience nausea and none vomited. With the exception of breast symptoms, other side effects were five times less common in women receiving danazol. These differences give danazol a clear advantage in terms of patient acceptability. Further experience will enable the efficacy of danazol to be evaluated and so determine whether this drug should become the preferred hormonal postcoital treatment.

My notes (saved in your browser only)

MeSH descriptors

Contraceptives, Oral Contraceptives, Oral, Combined Contraceptives, Postcoital Danazol Pregnadienes Adult Contraceptives, Oral Contraceptives, Oral, Combined Contraceptives, Postcoital Danazol Ethinyl Estradiol Ethinyl Estradiol Female Follow-Up Studies Humans Nausea Nausea Norgestrel Norgestrel Pregnadienes

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (29)

Cited by (7)

Source provenance

openalex
last seen: 2026-05-11T09:06:25.021373+00:00
pubmed
last seen: 2026-10-08T21:58:26.348914+00:00
unpaywall
last seen: 2026-10-14T06:23:58.021457+00:00
License: CC0 · commercial use OK