Changes in citrate concentration in the mouse uterus with experimentally-induced adenomyosis
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This study investigated alterations in uterine citrate concentration in mice experiencing experimentally induced adenomyosis.
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Abstract
Components of the uterine fluid in mice with experimentally-induced adenomyosis and in controls were examined by proton nuclear magnetic resonance spectroscopy. One of the components was markedly different in mice with adenomyosis. As this component was estimated to be citrate by comparison with authentic samples (standard spectrum), its levels in uterine fluid, uterine tissue and blood were determined by enzymatic analysis. The fluid obtained from the uterus with adenomyosis showed significantly lower concentration of citrate than that from normal uterus. However, the uterine tissue concentration was significantly higher in the experimental mice with adenomyosis. There was no difference in the blood citrate level between the experimental and the control groups. Since adenomyosis was induced by chronic hyperprolactinemia, the change of citrate level in the uterus with this lesion might imply some effects of prolactin (PRL) on metabolism and/or secretion of citrate. However, in normal mice, no significant change was demonstrated in uterine citrate concentration after short-term experimental modulation of the circulating PRL level. Thus, it is unlikely that PRL can regulate directly citrate metabolism in the uterus, indicating some other cause for changes in citrate level accompanying the development of adenomyosis.
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Cites (4)
- The elusive adenomyosis of the uterus 1962
- Animal model of uterine adenomyosis: Is prolactin a potent inducer of adenomyosis in mice? 1991
- Suppression of the development of uterine adenomyosis by danazol treatment in mice 1992
- Strain-difference in the induction of adenomyosis by intrauterine pituitary grafting in mice. 1982
Cited by (2)
References (22)
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Cited by (2)
SciLite annotations
chemicals 9
diethylcarbamazine citrate
diethylcarbamazine citrate
diethylcarbamazine citrate
diethylcarbamazine citrate
diethylcarbamazine citrate
diethylcarbamazine citrate
diethylcarbamazine citrate
diethylcarbamazine citrate
diethylcarbamazine citrate
organisms 5
transgenic mice
mus sp.
mus sp.
mus sp.
mus sp.
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- scilite
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