Investigating endometrial metabolic characteristics in patients with adenomyosis using gas chromatography/mass spectrometry

Ju Ren, Jiashuo Liu, Jingcong Dai, Li Wang, Fan He, Lina Hu
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2025 · vol. 45(1) , pp. 2503446 · doi:10.1080/01443615.2025.2503446 · PMID:40386953 · W4410502491
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Abstract

BACKGROUND: the expression of prolyl 4-hydroxylase subunit alpha 1 (P4HA1), a crucial enzyme that catalyses the conversion of proline to hydroxyproline. METHODS: , Cell Counting Kit-8, and 5-Ethynyl-2'-deoxyuridine (EdU) assays were used to investigate the effect of hydroxyproline on the proliferation of human endometrial stromal cells (hESCs). Additionally, a wound-healing assay was conducted to examine the effect of hydroxyproline on hESCs migration. RESULTS: = 0.002). CONCLUSION: Hydroxyproline levels were significantly elevated in the endometrial tissues of patients with adenomyosis. Furthermore, hydroxyproline promotes the proliferation and migration of hESCs. These findings provide new insights into the pathogenesis of adenomyosis and suggest potential therapeutic strategies.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Hydroxyproline Hydroxyproline Hydroxyproline Hydroxyproline Hydroxyproline Hydroxyproline

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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