Adenomyosis of the uterus: an enigma.

J R Thompson, Thompson, Thompson JR, Davion Rj, R J Davion
Journal of the National Medical Association · 1986 · vol. 78(4) , pp. 305–7 · PMID:3712468 · W194584499
article OA: green CC0 ⤵ 8 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-11 ⓘ

Adenomyosis, a poorly understood uterine condition, is associated with myometrial muscle pattern accentuation, multiparity, and endometrial hyperplasia, affecting women in their fourth and fifth decades.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-17 · read from full text ⓘ

This review article examines the historical and pathological understanding of adenomyosis, noting that its precise pathogenesis remains largely unknown despite long-standing clinical interest. The authors highlight a consensus regarding associations with myometrial muscle pattern accentuation, multiparity, and endometrial hyperplasia, while discussing competing theories on whether the condition results from glandular invasion due to basement membrane absence or general myometrial vulnerability. The text further observes that the condition predominantly affects women in their fourth and fifth decades and that preoperative diagnosis is infrequent. This paper is centrally about adenomyosis — specifically providing a general overview of its definition, associated risk factors, and diagnostic challenges without focusing on a specific treatment modality.

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Abstract

Adenomyosis has been an entity of some interest for many years, but little is known today of its pathogenesis. There is almost universal agreement that it is associated with an accentuation of the myometrial muscle pattern, multiparity, and endometrial hyperplasia. Some authors suggest that the myometrium is vulnerable to invasion by endometrial hyperplasia. Others postulate that the myometrium is vulnerable to invasion by endometrial glands because of the absence of a basement membrane. Women in the fourth and fifth decades of life are most commonly afflicted. Preoperative diagnosis is not common.
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Abstract Adenomyosis has been an entity of some interest for many years, but little is known today of its pathogenesis. There is almost universal agreement that it is associated with an accentuation of the myometrial muscle pattern, multiparity, and endometrial hyperplasia. Some authors suggest that the myometrium is vulnerable to invasion by endometrial hyperplasia. Others postulate that the myometrium is vulnerable to invasion by endometrial glands because of the absence of a basement membrane. Women in the fourth and fifth decades of life are most commonly afflicted. Preoperative diagnosis is not common. Full text PDFSelected References These references are in PubMed. This may not be the complete list of references from this article. - Huseby R. A., Thurlow S. Effects of prenatal exposure of mice to "low-dose" diethylstilbestrol and the development of adenomyosis associated with evidence of hyperprolactinemia. Am J Obstet Gynecol. 1982 Dec 15;144(8):939–949. doi: 10.1016/0002-9378(82)90189-2. [DOI] [PubMed] [Google Scholar]

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Uterine Neoplasms Adult Aged Endometriosis Endometriosis Female Humans Hysterectomy Middle Aged United States Uterine Neoplasms Uterine Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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