Epithelial Cells in Endometriosis and Adenomyosis Upregulate STING Expression

Hong Qu, Lihong Li, Tian‐Li Wang, Tian-Li Wang, Tamer Seckin, James Segars, James H. Segars, Ie‐Ming Shih, Ie-Ming Shih
Reproductive sciences (Thousand Oaks, Calif.) · 2020 · vol. 27(6) , pp. 1276–1284 · doi:10.1007/s43032-019-00127-z · PMID:32046461 · PMC7539849 · W2998014406
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study found significantly higher STING expression in the epithelial cells of endometriosis and adenomyosis compared to eutopic endometrium, correlating positively with intraepithelial lymphocyte infiltration.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

The study investigated whether the cytosolic DNA sensing pathway involving STING is activated in ectopic endometrium compared with eutopic endometrium by using immunohistochemistry to measure STING protein in normal endometrium, endometriosis, and adenomyosis. It analyzed 39 cases of endometriosis and/or adenomyosis with normal endometrium and assessed the relationship between STING expression in epithelial cells (versus stromal cells) and CD45+ intraepithelial lymphocyte density. STING expression was predominantly cytoplasmic in epithelial cells and was significantly higher in adenomyosis and endometriosis than in eutopic endometrium, with no significant difference between endometriosis and adenomyosis; STING levels positively correlated with intraepithelial lymphocyte infiltration. The paper does not explicitly state experimental limitations beyond the observational histologic correlation, and it does not directly measure downstream STING signaling activity or type I interferon outputs. This paper is centrally about endometriosis and adenomyosis—showing upregulation of epithelial STING expression in ectopic lesions and linking it to intraepithelial immune infiltration.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenomyosis Endometriosis Epithelial Cells Membrane Proteins Up-Regulation Adenomyosis Adenomyosis Adult Aged Endometriosis Endometriosis Endometrium Endometrium Epithelial Cells Female Humans Lymphocytes Lymphocytes Membrane Proteins Membrane Proteins

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