Moesin overexpression is a unique biomarker of adenomyosis

Rena Ohara, Hiroo Michikami, Yuko Nakamura, Akiko Sakata, Shingo Sakashita, Kaishi Satomi, Aya Shiba-Ishii, Aya Shiba‐Ishii, Junko Kano, Hiroyuki Yoshikawa, Masayuki Noguchi
Pathology international · 2014 · vol. 64(3) , pp. 115–122 · doi:10.1111/pin.12148 · PMID:24698421 · W1787532977
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Moesin was found to be significantly overexpressed and activated in adenomyosis lesions compared to normal endometrium, suggesting it as a unique biomarker.

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Abstract

Adenomyosis is characterized by extension of endometrial glands and stromal cells into the myometrium. Here we proved that 'moesin' is a unique biomarker of adenomyosis. We selected two cases of adenomyosis that had been surgically resected and fixed with formalin. Proteins were extracted from the infiltrating adenomyosis lesions and normal endometrium by tissue microdissection. The extracted proteins were examined using a LC-MS/MS system and the expression profiles of each region were compared. Two hundred and sixty proteins were detected, among which 73 were expressed more in adenomyosis than in normal endometrium. Among these proteins, we focused on overexpression of moesin in adenomyosis. Expression of moesin estimated semiquantitatively using an immunohistochemistry score was higher in adenomyosis than in normal endometrium. In particular, moesin was significanly overexpressed in stromal cells of adenomyosis than in those of normal endometrium. Relative to normal endometrium, moesin was also overexpressed at the RNA level in 9 of 14 cases of adenomyosis and at the protein level in all 14 cases. We also detected activated (phosphorylated) moesin in adenomyosis lesions. The present findings suggest that moesin is characteristically overexpressed and activated in adenomyosis, and that moesin activation may be related to extension of adenomyosis in the myometrium.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Endometrium Microfilament Proteins Myometrium Adenomyosis Adenomyosis Adenomyosis Biomarkers Biomarkers Endometrium Endometrium Female Humans Microfilament Proteins Myometrium Myometrium Phosphorylation

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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