Effect of soy isoflavones on endometriosis: interaction with estrogen receptor 2 gene polymorphism

Masaki Tsuchiya, Tsuchiya M, M Tsuchiya, Tsutomu Miura, Miura T, Hanaoka T, Tomoyuki Hanaoka, Iwasaki M, Motoki Iwasaki, Sasaki H, Hiroshi Sasaki, Tadao Tanaka, Tanaka T, Hiroyuki Nakao, Nakao H, Katoh T, Takahiko Katoh, Tsuyomu Ikenoue, Ikenoue T, Michinori Kabuto, Kabuto M, Shoichiro Tsugane, Tsugane S
Epidemiology (Cambridge, Mass.) · 2007 · vol. 18(3) , pp. 402–408 · doi:10.1097/01.ede.0000257571.01358.f9 · PMID:17474167 · W2068753144
Observational OA: closed CC0 ⤵ 39 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Higher urinary genistein and daidzein levels were associated with a decreased risk of advanced endometriosis, with gene polymorphisms potentially modifying the effect of genistein.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: Progression of endometriosis is considered estrogen-dependent. Dietary soy isoflavones may affect the risk of endometriosis, and polymorphisms in estrogen receptor genes may modify this association. We examined associations among soy isoflavone intake, estrogen receptor 2 (ESR2) gene polymorphisms and risk of endometriosis. METHODS: We recruited women age 20-45 years old who had consulted a university hospital for infertility in Tokyo, Japan in 1999 or 2000. A total of 138 eligible women were diagnosed laparoscopically and classified into 3 subgroups: control (no endometriosis), early endometriosis (stage I-II) and advanced endometriosis (stage III-IV). We measured urinary levels of genistein and daidzein as markers for dietary intake of soy isoflavones, and genotyped ESR2 gene RsaI polymorphisms. RESULTS: Higher levels of urinary genistein and daidzein were associated with decreased risk of advanced endometriosis (P for trend = 0.01 and 0.06, respectively) but not early endometriosis. For advanced endometriosis, the adjusted odds ratio for the highest quartile group was 0.21 (95% confidence interval = 0.06-0.76) for genistein and 0.29 (0.08-1.03) for daidzein, when compared with the lowest group. Inverse associations were also noted between urinary isoflavones and the severity of endometriosis (P for trend = 0.01 for genistein and 0.07 for daidzein). For advanced endometriosis, ESR2 gene RsaI polymorphism appeared to modify the effects of genistein (P for interaction = 0.03). CONCLUSIONS: Dietary isoflavones may reduce the risk of endometriosis among Japanese women.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Estrogen Receptor beta Glycine max Glycine max Isoflavones Polymorphism, Genetic Polymorphism, Genetic Adult Adult Diet Diet Endometriosis Endometriosis Endometriosis Estrogen Receptor beta Estrogen Receptor beta Female Female Genistein Genistein

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

Cited by (40)

Source provenance

europepmc
last seen: 2026-10-16T06:09:50.462052+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-10-08T21:04:24.806248+00:00
unpaywall
last seen: 2026-10-16T06:24:35.758740+00:00
License: CC0 · commercial use OK