Ioannis Georgiou

ORCID: 0000-0002-0308-5703 · 10 papers in corpus
2025
Letrozole at the Crossroads of Efficacy and Fetal Safety in Ovulation Induction: A Narrative Review.
Biomedicines ·doi:10.3390/biomedicines13092051

Letrozole, a third-generation aromatase inhibitor initially developed for breast cancer, has become the preferred first-line agent for ovulation induction (OI), particularly in women with polycystic ovary syndrome (PCOS). This narrative rev…

2024
Integrative Assessment of Seminal Plasma Biomarkers: A Narrative Review Bridging the Gap between Infertility Research and Clinical Practice.
Journal of clinical medicine ·doi:10.3390/jcm13113147

Infertility represents a significant global health challenge impacting millions of couples worldwide. Approximately half of all infertile couples exhibit compromised semen quality, indicative of diminished male fertility. While the diagnosi…

2021
Interplay Between mTOR and Hippo Signaling in the Ovary: Clinical Choice Guidance Between Different Gonadotropin Preparations for Better IVF.
Frontiers in endocrinology ·doi:10.3389/fendo.2021.702446

One of the most widely used types of assisted reproduction technology is the in vitro fertilization (IVF), in which women undergo controlled ovarian stimulation through the administration of the appropriate hormones to produce as many matur…

article 2020
Ultralong administration of gonadotropin-releasing hormone agonists before in vitro fertilization improves fertilization rate but not clinical pregnancy rate in women with mild endometriosis: a prospective, randomized, controlled trial
Fertility and sterility ·doi:10.1016/j.fertnstert.2019.12.018

ObjectiveTo evaluate the effects of gonadotropin-releasing hormone agonists (GnRH-a) on fertility in women with mild endometriosis who are undergoing in vitro fertilization and embryo transfer (IVF-ET) procedures.DesignProspective, randomiz…

2012
Aromatase (CYP19) gene variants influence ovarian response to standard gonadotrophin stimulation.
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-011-9673-y

PurposeThe association of cytochrome P450 aromatase gene CYP19(TTTA) ( n ) polymorphism with ovarian response to FSH stimulation was explored.MethodsThree h…

2011
Assessment of sperm chromatin condensation and ploidy status using flow cytometry correlates to fertilization, embryo quality and pregnancy following in vitro fertilization.
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-011-9611-z

PurposeSperm flow cytometry (SFC) was used to evaluate the association of sperm chromatin condensation and ploidy with fertilization, embryo development, pregnancy and abortion rates following IVF.MethodsConventional semen analysis was perf…

2011
The association of aromatase (CYP19) gene variants with sperm concentration and motility.
Asian journal of andrology ·doi:10.1038/aja.2010.144

The irreversible transformation of androgens into oestrogens is catalysed by cytochrome P450 aromatase. In the present study, we explored the contribution of the (TTTA)(n) polymorphism in the aromatase gene (CYP19) to sperm concentration an…

article 2008
The importance of the (TTTA)n polymorphism of aromatase (CYP19) gene in menarche
article 2005
Combined estrogen receptor α and estrogen receptor β genotypes influence the age of menarche
·doi:10.1093/humrep/dei326

BACKGROUND: Age at menarche has a strong genetic influence. We reported recently an association between the XbaI (351A-->C)and PvuII (397T-->C) polymorphisms of the estrogen receptor (ER)alpha gene with the age of menarche in Greek adolesce…

article 1999
Association of estrogen receptor gene polymorphisms with endometriosis
Fertility and sterility ·doi:10.1016/s0015-0282(99)00198-3

ObjectiveTo explore the association of the estrogen receptor two-allele (point) polymorphism and multiallele (microsatellite) polymorphism with endometriosis.DesignCase-control study.SettingGenetics and Endoscopy Unit, Department of Obstetr…