Estrogen Receptor Alpha (ERα) Pvu II 397 T/C Related Genotypes and Alleles are Associated with Higher Susceptibilities of Endometriosis

Vera Permatasari, Muhammad Irsan Saleh, Sri Nita
In: Journal of Physics: Conference Series · 2020 · vol. 1485(1) , pp. 012011 · doi:10.1088/1742-6596/1485/1/012011 · W3025998772
Observational OA: diamond CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-12 ⓘ

This study found that specific ERα 397 T/C genotypes and alleles are significantly correlated with an increased susceptibility to endometriosis in women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-10-22 · read from full text ⓘ

This study investigated the association between estrogen receptor alpha (ERα) Pvu II 397 T/C polymorphisms and endometriosis risk by comparing genotype frequencies in patients with the condition against healthy controls. Using PCR-RFLP analysis on seventy participants, researchers found significantly higher frequencies of the C allele and specific genotypes in the endometriosis group compared to the control group. The results indicated a statistically significant correlation between these genetic variations and susceptibility to the disease, supporting the role of ERα signaling in its pathogenesis. This paper is centrally about endometriosis — specifically examining genetic susceptibility factors related to estrogen receptor polymorphisms.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Abstract Endometriosis is an estrogen dependent disease that is proved by its development in reproductive age and the decrease after menopause or ovariectomy. Endometriosis characterized by the growth of endometrial outside the uterine cavity, which is found in women with subfertility and pelvic pain problems. Effect of the estrogen hormone depends on the binding to its receptor. Estrogen receptor alpha (ERα) polymorphisms which admit by Pvu II enzyme restriction has associate to some women’s disease like endometriosis. This Study aimed to determine the correlation between ERα 397 T/C with the risk of endometriosis. There were 70 samples which were divided into 2 groups: 35 cases (endometriosis group) and 35 controls (non-endometriosis group). The determination of genotypes and allotypes used PCR-RFLP method and the data analysis by chi square test α<0,05.The results showed that genotype frequencies of case group are 11,4% TT, 54,3% TC and 12% CC while genotype of control group are 34,3% TT, 51,4% TC and 14,3% CC with p value 0,032. Allele frequencies of case group are 38,6% T and 61,4% C while control group are 60% T and 40% C with p value 0,011. Conclusion: there is a significant correlation between the genotype and allele polymorphism of ERα gene 397 T/C with the risk of endometriosis.
Full text 1,543 characters · extracted from oa-doi-fallback · click to expand
Abstract Endometriosis is an estrogen dependent disease that is proved by its development in reproductive age and the decrease after menopause or ovariectomy. Endometriosis characterized by the growth of endometrial outside the uterine cavity, which is found in women with subfertility and pelvic pain problems. Effect of the estrogen hormone depends on the binding to its receptor. Estrogen receptor alpha (ERα) polymorphisms which admit by Pvu II enzyme restriction has associate to some women’s disease like endometriosis. This Study aimed to determine the correlation between ERα 397 T/C with the risk of endometriosis. There were 70 samples which were divided into 2 groups: 35 cases (endometriosis group) and 35 controls (non-endometriosis group). The determination of genotypes and allotypes used PCR-RFLP method and the data analysis by chi square test α<0,05.The results showed that genotype frequencies of case group are 11,4% TT, 54,3% TC and 12% CC while genotype of control group are 34,3% TT, 51,4% TC and 14,3% CC with p value 0,032. Allele frequencies of case group are 38,6% T and 61,4% C while control group are 60% T and 40% C with p value 0,011. Conclusion: there is a significant correlation between the genotype and allele polymorphism of ERα gene 397 T/C with the risk of endometriosis. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (23)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK