Analysis of the transforming growth factor beta1 gene -509 C/T polymorphism in patients with advanced-stage endometriosis

Jinju Kim, Kim JJ, Jin Ju Kim, Choi YM, Young Min Choi, Seon Ha Choung, Choung SH, Sang Ho Yoon, Yoon SH, Kyu Sup Lee, Lee KS, Seung Yup Ku, Ku SY, Seung‐Yup Ku, Jung Gu Kim, Kim JG, Moon SY, Shin Yong Moon
Fertility and sterility · 2009 · vol. 93(7) , pp. 2121–2124 · doi:10.1016/j.fertnstert.2009.01.082 · PMID:19249027 · W2074954274
Observational OA: closed CC0 ⤵ 10 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

This study investigated the association between the TGFB1 gene -509 C/T polymorphism and advanced-stage endometriosis in patients.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To investigate whether the transforming growth factor beta (TGF-beta) gene -509 C/T polymorphism is associated with susceptibility to advanced-stage endometriosis. DESIGN: Case-control study. SETTING: University department of obstetrics and gynecology. PATIENT(S): Women with advanced-stage endometriosis (n = 485) and without endometriosis (n = 352). INTERVENTION(S): Genotyping by real-time polymerase chain reaction using a Taqman assay. MAIN OUTCOME MEASURE(S): Genotype distribution and allele frequency of the -509 C/T polymorphism in the TGF-beta1 gene. RESULT(S): The genotype distribution of the TGF-beta1 gene -509 C/T polymorphism in the endometriosis group was not different from that of the control group (CC/CT/TT rates were 29.3%/48.2%/22.5% and 27.3%/50.3%/22.4% for the endometriosis and control groups, respectively). Further subgroup analyses according to the stage of endometriosis or bilaterality of ovarian endometrioma also revealed no significant differences in the genotype distribution between each of the subgroups and the control group. CONCLUSION(S): These results suggest that the TGF-beta1 -509 C/T polymorphism may not be associated with an increased risk for advanced-stage endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Diseases Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Transforming Growth Factor beta1 Adult Adult Case-Control Studies Case-Control Studies Disease Progression Disease Progression DNA Mutational Analysis DNA Mutational Analysis Endometriosis Endometriosis Female Female Gene Frequency Gene Frequency Genotype

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (24)

Cited by (10)

Source provenance

europepmc
last seen: 2026-10-12T06:17:10.165071+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:06:15.453410+00:00
unpaywall
last seen: 2026-09-17T06:32:46.214484+00:00
License: CC0 · commercial use OK